f The Maintenance of Plasmid-containing Organisms in Populations of Escherichia coli
- Authors: ROBERT B. HELLING, THOMAS KINNEY, JULIAN ADAMS
- Microbiology, March 1981 123: 129-141, doi: 10.1099/00221287-123-1-129
- Subject: Article
- Published Online:
Populations of Escherichia coli containing a small non-conjugative plasmid were grown in carbon-limited continuous culture. For all plasmids tested the presence of the plasmid lowered the growth rate of the host bacterium, and the proportion of plasmid-containing organisms in the total population declined initially. However, periodically, adaptive changes occurred in plasmid-containing organisms which increased their growth rate. This resulted in oscillations in the proportion of plasmid-containing organisms, and the delayed loss of the plasmid from the population.
© Society for General Microbiology 1981 | Published by the Microbiology Society
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