RT Journal Article SR Electronic(1) A1 Helling Robert, B. A1 Kinney, Thomas A1 Adams, JulianYR 1981 T1 The Maintenance of Plasmid-containing Organisms in Populations of Escherichia coli JF Microbiology, VO 123 IS 1 SP 129 OP 141 DO https://doi.org/10.1099/00221287-123-1-129 PB Microbiology Society, SN 1465-2080, AB Populations of Escherichia coli containing a small non-conjugative plasmid were grown in carbon-limited continuous culture. For all plasmids tested the presence of the plasmid lowered the growth rate of the host bacterium, and the proportion of plasmid-containing organisms in the total population declined initially. However, periodically, adaptive changes occurred in plasmid-containing organisms which increased their growth rate. This resulted in oscillations in the proportion of plasmid-containing organisms, and the delayed loss of the plasmid from the population., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-123-1-129