1887

Abstract

strain GLA0 (= ETH 22794) produces hydroxystreptomycin and has a high natural resistance to hydroxystreptomycin, dihydrostreptomycin and streptomycin. The wild-type strain gives rise spontaneously to streptomycin-sensitive (StrS) variants at a frequency of 0.2 to 1.4%. These mutants lack streptomycin phosphotransferase activity responsible for the wild-type resistance to streptomycin group antibiotics and are unable to produce detectable amounts of hydroxystreptomycin.

Mapping experiments showed that the marker lies between the chromosomal markers and on the linkage map of The molecular basis for instability of this marker is as yet unknown.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-129-2-519
1983-02-01
2024-04-23
Loading full text...

Full text loading...

/deliver/fulltext/micro/129/2/mic-129-2-519.html?itemId=/content/journal/micro/10.1099/00221287-129-2-519&mimeType=html&fmt=ahah

References

  1. Baumann R., Hütter R., Hopwood D. A. 1974; Genetic analysis in a melanin-producing streptomycete: Streptomyces glaucescens. Journal of General Microbiology 81:463–474
    [Google Scholar]
  2. Delić V., Hopwood D. A., Friend E. J. 1970; Mutagenesis by N-methyl-N′-nitro-N-nitroso- guanidine (NTG) in Streptomyces coelicolor. Mutation Research 9:167–182
    [Google Scholar]
  3. Demerec M., Adelberg A., Clark A. J., Hartman P. E. 1966; A proposal for a uniform nomenclature in bacterial genetics. Genetics 54:61–76
    [Google Scholar]
  4. Fedorenko V. A., Danilenko V. N. 1980; Instability of natural multiple drug resistance in actinomycetes. Antibiotiki 25:170–174
    [Google Scholar]
  5. Freeman R. F., Hopwood D. A. 1978; Unstable naturally occurring resistance to antibiotics in Streptomyces. Journal of General Microbiology 106:377–381
    [Google Scholar]
  6. Freeman R. F., Bibb M. J., Hopwood D. A. 1977; Chloramphenicol acetyltransferase-independent chloramphenicol resistance in Streptomyces coelicolorA3(2). Journal of General Microbiology 98:453–465
    [Google Scholar]
  7. Friend E. J., Warren M., Hopwood D. A. 1978; Genetic evidence for a plasmid controlling fertility in an industrial strain of Streptomyces rimosus. Journal of General Microbiology 106:201–206
    [Google Scholar]
  8. Gregory K. F., Huang J. C. C. 1964a; Tyrosinase inheritance in Streptomyces scabies. I. Genetic recombination. Journal of Bacteriology 87:1281–1286
    [Google Scholar]
  9. Gregory K. F., Huang J. C. C. 1964b; Tyrosinase inheritance in Streptomyces scabies. II. Induction of tyrosinase deficiency by acridine dyes. Journal of Bacteriology 87:1287–1294
    [Google Scholar]
  10. Hopwood D. A. 1978; Extrachromosomally determined antibiotic production. Annual Review of Microbiology 32:373–392
    [Google Scholar]
  11. Hütter R., Kieser T., Crameri R., Hintermann G. 1981; Chromosomal instability in Streptomyces glaucescens. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene (supplement) 11:551–559
    [Google Scholar]
  12. Kirby R. 1978; An unstable element affecting the production of the antibiotic holomycin by Streptomyces clavuligerus. FEMS Microbiology Letters 3:283–286
    [Google Scholar]
  13. Kirby R., Lewis E. 1981; Unstable genetic elements affecting streptomycin resistance in the streptomycin-producing organisms Streptomyces gri- seus NCIB 8506 and Streptomyces bikiniensisISP 5235. Journal of General Microbiology 122:351–355
    [Google Scholar]
  14. Lanfaloni L., Micheli M. R., Sermonti G. 1980; “Salto” del transposone SCTnI su un plasmide in Streptomyces coelicolor. Rivista di biologia 73:431–433
    [Google Scholar]
  15. Ono H., Crameri R., Hintermann G., Hütter R. 1983; Hydroxystreptomycin production and resistance in Streptomyces glaucescens. Journal of General Microbiology 129:529–537
    [Google Scholar]
  16. Pogell B. A. 1979; Regulation of aerial mycelium formation in streptomycetes. In Proceedings of the 3rd International Symposium on Genetics of Industrial Microorganisms pp. 218–224 Sebek O. K., Laskin A. I. Edited by Washington, D.C.:: American Society for Microbiology.;
    [Google Scholar]
  17. Pridham T. G., Anderson P., Foley C., Linden-Felser L. A., Hesseltine C. W., Benedict R. G. 1956/7; A selection of media for maintenance and taxonomic study of Streptomyces. Antibiotics Annual947–953
    [Google Scholar]
  18. Puzynina G. G., Danilenko V. N., Vasil’Chenko L. G., Mkrtumian N. M., Lomovskaya N. D. 1979; Determination of the erythromycin resistance of Streptomyces coelicolorA3(2). Genetika 15:1151–1157 (English translation)
    [Google Scholar]
  19. Redshaw P. A., Mccann P. A., Pentella M. A., Pogell B. M. 1979; Simultaneous loss of multiple differentiated functions in aerial mycelium-negative isolates of streptomycetes. Journal of Bacteriology 137:891–899
    [Google Scholar]
  20. Schrempf H. 1981; Function of plasmid genes in streptomycetes. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene (supplement) 11:545–550
    [Google Scholar]
  21. Sermonti G., Petris A., Micheli R., Lanfaloni L. 1977; A factor involved in chloramphenicol resistance in Streptomyces coelicolorA3(2): its transfer in the absence of the fertility factor. Journal of General Microbiology 100:347–353
    [Google Scholar]
  22. Sermonti G., Petris A., Micheli R., Lanfaloni L. 1978; Chloramphenicol resistance in Streptomyces coelicolorA3(2): possible involvement of a transposable element. Molecular and General Genetics 164:99–103
    [Google Scholar]
  23. Sermonti G., Lanfaloni L., Micheli R. 1980; A jumping gene in Streptomyces coelicolorA3(2). Molecular and General Genetics 177:453–458
    [Google Scholar]
  24. Shaw P. D., Piwowarski J. 1977; Effects of ethidium bromide and acriflavine on streptomycin production by Streptomyces bikiniensis. Journal of Antibiotics 30:404–408
    [Google Scholar]
  25. Suter M. A. 1978 Isolierung und Charakterisierung von Melanin-negativen Mutantenaus Streptomyces glaucescens. Thesis no. 6276 Eidgenössische Technische Hochschule Zürich, Switzerland.:
    [Google Scholar]
  26. Suter M., Hütter R., Leisinger TH. 1978; Mutants of Streptomyces glaucescens affected in the production of extracellular enzymes. In Genetics of the Actinomycetales pp. 61–64 Freerksen E., Tamok I., Thumin J. H. Edited by Stuttgart & New York:: Gustav Fischer Verlag.;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-129-2-519
Loading
/content/journal/micro/10.1099/00221287-129-2-519
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error