RT Journal Article SR Electronic(1) A1 Crameri, Reto A1 Kieser, Tobias A1 Ono, Hideo A1 Sanchez, Jesus A1 Hüter, RalfYR 1983 T1 Chromosomal Instability in Streptomyces glaucescens: Mapping of Streptomycin-sensitive Mutants JF Microbiology, VO 129 IS 2 SP 519 OP 527 DO https://doi.org/10.1099/00221287-129-2-519 PB Microbiology Society, SN 1465-2080, AB Streptomyces glaucescens strain GLA0 (= ETH 22794) produces hydroxystreptomycin and has a high natural resistance to hydroxystreptomycin, dihydrostreptomycin and streptomycin. The wild-type strain gives rise spontaneously to streptomycin-sensitive (StrS−) variants at a frequency of 0.2 to 1.4%. These mutants lack streptomycin phosphotransferase activity responsible for the wild-type resistance to streptomycin group antibiotics and are unable to produce detectable amounts of hydroxystreptomycin. Mapping experiments showed that the strS marker lies between the chromosomal markers lys-2 and ura-3 on the linkage map of S. glaucescens. The molecular basis for instability of this marker is as yet unknown., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-129-2-519