f The Role of Common and Type-specific Pilus Antigenic Domains in Adhesion and Virulence of Gonococci for Human Epithelial Cells
- Authors: M. Virji, J. E. HECKELS
- First Published Online: 01 May 1984, Microbiology 130: 1089-1095, doi: 10.1099/00221287-130-5-1089
- Subject: Pathogenicity And Medical Microbiology
- Issue Published:
A panel of monoclonal antibodies with varying pilus specificities ranging from cross-reacting to type-specific has been used to investigate the role of conserved and variable antigenic domains in the adhesion of gonococci to human epithelial cells. The binding of 125I-labelled α pili from strain P9 to buccal epithelial cells was inhibited by three type-specific but not by two cross-reacting antibodies. Four type-specific antibodies inhibited the binding of γ pili while the two cross-reacting antibodies were again without effect. The virulence of the variants P9-2 (α pili) and P9-35 (γ pili) for Chang conjunctiva epithelial cells was similarly reduced only in the presence of relevant type-specific antibodies. These results indicate the importance of variable antigenic domains in the adhesion of gonococci to human epithelial cells.
© Society for General Microbiology 1984 | Published by the Microbiology Society
Article metrics loading...
Full text loading...
Author and Article Information
/content/journal/micro/10.1099/00221287-130-5-1089dcterms_title,dcterms_subject,pub_serialTitlepub_serialIdent:journal/micro AND -contentType:BlogPost104
/content/journal/micro/10.1099/00221287-130-5-1089dcterms_title,dcterms_subject-pub_serialIdent:journal/micro AND -contentType:BlogPost104
Figure data loading....