1887

Abstract

Summary: The accumulation of amino acids and the excretion of ammonium have been studied in various ammonium assimilation mutants, together with the labelling of glutamine in the presence of [U-C]sucrose when grows on glutamine as the nitrogen source. Ammonium coming from glutamine degradation by the ω-amidase pathway is assimilated by NADP-dependent glutamate dehydrogenase and glutamine synthetase. The operation of these enzymes results in a cycling of glutamine that seems to be essential for cell growth. In addition, glutamine is also converted to glutamate by glutamate synthase.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-131-12-3237
1985-12-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/micro/131/12/mic-131-12-3237.html?itemId=/content/journal/micro/10.1099/00221287-131-12-3237&mimeType=html&fmt=ahah

References

  1. Calderón J., Morett E., Mora J. 1985; ω-Amidase pathway in the degradation of glutamine in Neurospora crassa . Journal of Bacteriology 161:807–809
    [Google Scholar]
  2. Choong-Hyun K., Hollocher T. H. 1982; 13N isotope studies on the pathway of ammonia assimilation in Bacillus megaterium and Escherichia coli . Journal of Bacteriology 151:358–366
    [Google Scholar]
  3. Cooper A. J. L., Meister A. 1977; The glutamine transaminase-ω-amidase pathway.. CRC Critical Reviews in Biochemistry 4:281–303
    [Google Scholar]
  4. Dávila G., Brom S., Mora Y., Palacios R., Mora J. 1983; Genetic and biochemical characterization of glutamine synthetase from Neurospora crassa glutamine auxotrophs and their revertants.. Journal of Bacteriology 156:993–1000
    [Google Scholar]
  5. Espín G., Mora J. 1978; Effect of the deprivation of amino acids on conidia of Neurospora crassa . Journal of General Microbiology 104:233–240
    [Google Scholar]
  6. Espín G., Palacios R., Mora J. 1979; Glutamine metabolism in nitrogen-starved conidia of Neurospora crassa . Journal of General Microbiology 115:59–68
    [Google Scholar]
  7. Fincham J. R. S. 1950; Mutant strains of Neurospora deficient in aminating ability.. Journal of Biological Chemistry 182:61–73
    [Google Scholar]
  8. Hummelt G., Mora J. 1980a; NADH-dependent glutamate synthase and nitrogen metabolism in Neurospora crassa . Biochemical and Biophysical Research Communications 92:127–133
    [Google Scholar]
  9. Hummelt G., Mora J. 1980b; Regulation and function of glutamate synthase in Neurospora crassa . Biochemical and Biophysical Research Communications 96:1688–1694
    [Google Scholar]
  10. Katz J., Rognstad R. 1976; Futile cycles in the metabolism of glucose.. Current Topics in Cell Regulation 10:237–289
    [Google Scholar]
  11. Lara M., Blanco L., Campomanes M., Calva E., Mora J. 1982; Physiology of ammonium assimilation in Neurospora crassa . Journal of Bacteriology 150:105–112
    [Google Scholar]
  12. Marzluf G. A. 1981; Regulation of nitrogen metabolism and gene expression in fungi.. Microbiological Reviews 45:437–461
    [Google Scholar]
  13. Prusiner S., Stadtman E. R. (eds) 1973 The enzymes of glutamine metabolism pp 331–573 New York: Academic Press;
    [Google Scholar]
  14. Vaca G., Mora J. 1977; Nitrogen regulation of arginase in Neurospora crassa . Journal of Bacteriology 131:755–567
    [Google Scholar]
  15. Vichido I., Mora Y., Quinto C., Palacios R., Mora J. 1978; Nitrogen regulation of glutamine synthetase in Neurospora crassa . Journal of General Microbiology 106:251–259
    [Google Scholar]
  16. Vogel H. J. 1964; Distribution of lysine pathways among fungi: evolutionary implications.. American Naturalist 98:435–446
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-131-12-3237
Loading
/content/journal/micro/10.1099/00221287-131-12-3237
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error