1887

Abstract

Summary: A comparative study was made of the virulence and immunogenicity in mice or guinea pigs of strains harbouring 110 MDa and/or 60 MDa plasmids. Strains cured of the 110 MDa or the 60 MDa plasmid were more than 100-fold less virulent to mice than were the parental strains harbouring these plasmids. Guinea-pigs immunized with plasmid-free derivatives of the non-encapsulated vaccine strain 34F2 showed no resistance to challenge with strain 17JB, which harbours both 110 MDa and 60 MDa plasmids, suggesting that the derivative strains had lost their immunizing ability against anthrax.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-132-2-557
1986-02-01
2024-04-23
Loading full text...

Full text loading...

/deliver/fulltext/micro/132/2/mic-132-2-557.html?itemId=/content/journal/micro/10.1099/00221287-132-2-557&mimeType=html&fmt=ahah

References

  1. Ando K., Akaike Y., Azuma R. 1961; Identification of Bacillus anthracis by means of γ bacteriophage. National Institute of Animal Health Quarterly 41:37–41
    [Google Scholar]
  2. Beall F. A., Taylor M. J., Thorne C. B. 1961; Rapid lethal effect in rats of a third component found upon fractionating the toxin of Bacillus anthracis. Journal of Bacteriology 83:1274–1280
    [Google Scholar]
  3. Elwell L. P., Shipley P. L. 1980; Plasmid-mediated factors associated with virulence of bacteria to animals. Annual Review of Microbiology 34:465–496
    [Google Scholar]
  4. Fish D. C., Mahlandt B. G., Dobbs J. P., Lincoln R. E. 1968; Purification and properties of in vitro-produced anthrax toxin components. Journal of Bacteriology 95:907–918
    [Google Scholar]
  5. Green B. D., Battisti L., Koehler T. M., Thorne C. B., Ivins B. E. 1985; Demonstration of a capsule plasmid in Bacillus anthracis. Infection and Immunity 49:291–297
    [Google Scholar]
  6. Mikesell P., Ivins B. E., Ristroph J. D., Dreier T. M. 1983; Evidence for plasmid-mediated toxin production in Bacillus anthracis. Infection and Immunity 39:371–376
    [Google Scholar]
  7. Preisz H. 1909; Experimented Studien fiber Virulenz, Empfänglichkeit und Immunität beim Milz-brand. Zentralblatt für Bakteriologie, Parasitenkunde und Infectionskrankheiten, Abteilung Originate 49:341–452
    [Google Scholar]
  8. Shipley P. L., Dallas W. S., Dougan G., Falkow S. 1979; Expression of plasmid genes in pathogenic bacteria. In Microbiology – 1979, pp. 176–180 Edited by D. Schlessinger. Washington, DC: American Society for Microbiology.
    [Google Scholar]
  9. Smith H. 1960; Studies on organisms grown in vivo to reveal the basesof microbial pathogenicity. Annals of the New York Academy of Sciences 88:1213–1226
    [Google Scholar]
  10. Stanley J. L., Smith H. 1961; Purification of factor I and recognition of a third factor of anthrax toxin. Journal of General Microbiology 26:49–66
    [Google Scholar]
  11. Stanley J. L., Smith H. 1963; The three factors of anthrax toxin: their immunogenicity and lack of demonstrable enzymic activity. Journal of General Microbiology 31:329–337
    [Google Scholar]
  12. Uchida I., Sekizaki T., Hashimoto K., Terakado N. 1985; Association of the encapsulation of Bacillus anthracis with a 60 megadalton plasmid. Journal of General Microbiology 131:363–367
    [Google Scholar]
  13. Vodkin M. H., Leppla S. H. 1983; Cloning of the protective antigen of Bacillus anthracis. Cell 34:693–697
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-132-2-557
Loading
/content/journal/micro/10.1099/00221287-132-2-557
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error