An Immunoprotective Monoclonal Antibody Directed against Leptospira interrogans serovar copenhageni
Schoone, G. J. and Everard, C. O. R. and Korver, H. and Carrington, D. G. and Inniss, V. A. and Baulu, J. and Terpstra, W. J.,, 135, 73-78 (1989),
doi = https://doi.org/10.1099/00221287-135-1-73,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= A monoclonal antibody (mAb) was prepared by hybridoma technology in BALB/c mice immunized to Leptospira interrogans serovar copenhageni. This mAb agglutinated serovars copenhageni and icterohaemorrhagiae to high titres and protected hamsters, dogs and monkeys against challenge with a virulent strain of serovar copenhageni. The mAb gave protection to hamsters at dilutions up to 1 in 1000; at a 1 in 10 dilution the protective effect lasted for at least two weeks. Biochemical analysis by SDS-PAGE and Western blotting indicated that this mAb reacred with an epitope of a carbohydrate nature.,
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