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Volume 144, Issue 1

Analysis of fission yeast DNA structure checkpoints:1996 Fleming Lecture Free

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Keyword(s): cell cycle control , DNA structure checkpoints , rad mutants , Saccharomyces cerevisiae and Schizosaccharomyces pombe
© Society for General Microbiology 1998
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1998-01-01
2024-04-18
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References

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  2. Al-Khodairy F., Carr A. M. 1992; DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. . EMBO J 11:1343–1350
     [Google Scholar]
  3. Al-Khodairy F., Fotou E., Sheldrick K. S., Griffiths D. J. F., Lehmann A. R., Carr A. M. 1994; Identification and characterisation of new elements involved in checkpoints and feedback controls in fission yeast. Mol Biol Cell 5:147–160
     [Google Scholar]
  4. Al-Khodairy F., Enoch T., Hagan I. M., Carr A. M. 1995; The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin- conjugating enzyme required for normal mitosis. J Cell Sci 108:475–486
     [Google Scholar]
  5. Allen J. B., Zhou Z., Siede W., Friedberg E. C., Elledge S. J. 1994; The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev 8:2401–2415
     [Google Scholar]
  6. Barbet N. C., Carr A. M. 1993; Fission yeast weel protein kinase is not required for DNA damage-dependent mitotic arrest. Nature 364:824–827
     [Google Scholar]
  7. Bentley N. J., Holtzman D. A., Flaggs G., Keegan K. S., DeMaggio A., Ford J. C., Hoekstra M., Carr A. M. 1996; The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J 15:6641–6651
     [Google Scholar]
  8. Carr A. M. 1994; Radiation checkpoints in model systems. Int J Radiat Biol 66:S133–S139
     [Google Scholar]
  9. Carr A. M. 1997; Control of cell cycle arrest by the Meclsc/ Rad3sp DNA structure checkpoint pathway. Curr Opitt Genet Dev 7:93–98
     [Google Scholar]
  10. Cimprich K. A., Shin T. B., Keith C. T., Schreiber S. L. 1996; cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci USA 93:2850–2855
     [Google Scholar]
  11. Ellis N. A. 1997; DNA helicases in inherited human disorders. Curr Opin Genet Dev 7:354–363
     [Google Scholar]
  12. Ellis N. A., Groden J., Ye T. -Z., Straughen J., Lennon D. J., Ciocci S., Proytcheva M., German J. 1995; The Bloom’s syndrome gene product is homologous to RecQ helicases. Cell 83:655–666
     [Google Scholar]
  13. Enoch T., Nurse P. 1990; Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60:665–673
     [Google Scholar]
  14. Enoch T., Carr A. M., Nurse P. 1992; Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev 6:2035–2046
     [Google Scholar]
  15. Flaggs G., Plug A. W., Dunks K. M. 9 other authors 1997; ATM- and ATR- dependent interactions of a mammalian CHK1 homolog with meiotic chromosomes. Curr Biol 7:977–986
     [Google Scholar]
  16. Ford J. C., Al-Khodairy F., Fotou E., Sheldrick K. S., Griffiths D. J. F., Carr A. M. 1994; 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Science 265:533–535
     [Google Scholar]
  17. Furnari B., Rhind N., Russell P. 1997; Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science 211:1495–1497
     [Google Scholar]
  18. Griffiths D. J. F., Barbet N. C., McCready S., Lehmann A. R., Carr A. M. 1995; Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J 14:5812–5823
     [Google Scholar]
  19. Hartwell L. H., Kastan M. B. 1994; Cell cycle control and cancer. Science 266:1821–1828
     [Google Scholar]
  20. Jeggo A. P., Taccioli G. E., Jackson S. P. 1995; Menage à trois: double strand break repair, V(D) J recombination and DNA-PK. Bioessays 17:949–957
     [Google Scholar]
  21. Keegan K. S., Holtzman D. A., Plug A. W. 10 other authors 1996; The Atr and Atm protein-kinases associate with different sites along meiotically pairing chromosomes. Genes Dev 10:2423–2437
     [Google Scholar]
  22. Kiser G. L., Weinert T. A. 1996; Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7:703–718
     [Google Scholar]
  23. Kostrub C. F., Al-Khodairy F., Ghazizadeh H., Carr A. M., Enoch T. 1997; Molecular analysis of hus1+, a fission yeast gene required for S-M and DNA damage checkpoints. Mol Gen Genet 254:389–399
     [Google Scholar]
  24. Lehmann A. R. 1996; Molecular biology of DNA repair in the fission yeast Schizosaccharomyces pombe . Mutat Res 363:147–161
     [Google Scholar]
  25. Lindsay H. D., Griffiths D. J. F., Edwards R., Murray J. M., Christensen P. U., Walworth N., Carr A. M. 1998; S-phase specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe . Genes Dev (in press)
    [Google Scholar]
  26. Long K. E., Sunnerhagen P., Subramani S. 1994; The Schizosaccharomyces pombe rad1 gene consists of three exons and the cDNA sequence is partially homologous to the Ustilago maydis REC1 cDNA. Gene 148:155–159
     [Google Scholar]
  27. Lydall D., Nikolsky Y., Bishop D. K., Weinert T. 1996; A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature 383:840–843
     [Google Scholar]
  28. Murakami H., Okayama H. 1995; A kinase from fission yeast responsible for blocking mitosis in S phase. Nature 374:817–819
     [Google Scholar]
  29. Muris D. F. R., Vreeken K., Schmidt H., Ostermann K., Clever B., Lohman P. H. M., Pastink A. 1996; Homologous recombination in the fission yeast Schizosaccharomyces pombe: different requirements for the rhp51+, rhp54+ and rad22+ genes. Curr Genet 31:248–254
     [Google Scholar]
  30. Murray J. M., Carr A. M., Lehmann A. R., Watts F. Z. 1991; Cloning and characterization of the DNA repair gene, rad9, from Schizosaccharomyces pombe . Nucleic Acids Res 19:3525–3531
     [Google Scholar]
  31. Murray J. M., Lindsay H. D., Munday C. A., Carr A. M. 1997; Role of Schizosaccharomyces pombe RecQ homologue, recombination and checkpoint genes in UV damage tolerance. Mol Cell Biol 17: (in press)
    [Google Scholar]
  32. OʹConnell M. J., Raleigh J. M., Verkade H. M., Nurse P. 1997; Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J 16:545–554
     [Google Scholar]
  33. Pati D., Keller C., Groudine M., Plon S. E. 1997; Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Mol Cell Biol 17:3037–3046
     [Google Scholar]
  34. Peng C. -Y., Graves P. R., Thoma R. S., Wu Z., Shaw A. S., Piwnica-Worms H. 1997; Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277:1501–1505
     [Google Scholar]
  35. Rao P. N., Johnson R. T. 1970; Mammalian cell fusion studies on the regulation of DNA synthesis and mitosis. Nature 225:159–164
     [Google Scholar]
  36. Rowley R., Subramani S., Young P. G. 1992; Checkpoint controls in Schizosaccharomyces pombe: radl . EMBO J 11:1335–1342
     [Google Scholar]
  37. Sanchez Y., Desany B. A., Jones W. J., Liu Q., Wang B., Elledge S. J. 1996; Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357–360
     [Google Scholar]
  38. Sanchez Y., Wong C., Thoma R. S., Richman R., Wu Z., Piwnica-Worms H., Elledge S. J. 1997; Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277:1497–1501
     [Google Scholar]
  39. Savitsky K., Bar-Shira A., Gilad S. 27 other authors 1995; A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749–1753
     [Google Scholar]
  40. Sheldrick K. S., Carr A. M. 1993; Feedback controls and G2 checkpoints: fission yeast as a model system. Bioessays 15:775–782
     [Google Scholar]
  41. Stewart E., Chapman C., Al-Khodairy F., Carr A. M., Enoch T. 1997; Rhq1 +, a fission yeast gene related to the Bloom’s and Werner’s syndrome genes, is required for reversible S-phase arrest. EMBO J 16:2682–2692
     [Google Scholar]
  42. Sun Z., Fay D. S., Marini F., Foiani M., Stern D. F. 1996; Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev 10:395–406
     [Google Scholar]
  43. Sunnerhagen P., Seaton B. L., Nasim A., Subramani S. 1990; Cloning and analysis of a gene involved in DNA repair and recombination, the rad1 gene of Schizosaccharomyces pombe . Mol Cell Biol 10:3750–3760
     [Google Scholar]
  44. Taylor E. M., McFarlane R. J., Price C. 1996; 5-Azacytidine treatment of the fission yeast leads to cytotoxicity and cell cycle arrest. Mol Gen Genet 253:128–137
     [Google Scholar]
  45. Thelen M. P., Onel K., Holloman W. K. 1994; The REC1 gene of Ustilago maydis involved in the cellular response to DNA damage encodes an exonuclease. J Biol Chem 269:747–754
     [Google Scholar]
  46. Walworth N., Bernards R. 1996; rad-dependent responses of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271:353–356
     [Google Scholar]
  47. Walworth N., Davey S., Beach D. 1993; Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363:368–371
     [Google Scholar]
  48. Weinert T. A., Hartwell L. H. 1988; The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae . Science 241:317–322
     [Google Scholar]
  49. Weinert T. A., Kiser G. L., Hartwell L. H. 1994; Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8:652–665
     [Google Scholar]
  50. Yu C. -E., Oshima J., Fu Y. -H. 10 other authors 1996; Positional cloning of the Werner’s syndrome gene. Science 272:258–262
     [Google Scholar]
  51. Aboussekhra A., Vialard J. E., Morrison D. E., de la Torre-Ruiz M. A., Cernakova L., Fabre F., Lowndes N. F. 1996; A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription. EMBO J 15:3912–3922
     [Google Scholar]
  52. Al-Khodairy F., Carr A. M. 1992; DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. . EMBO J 11:1343–1350
     [Google Scholar]
  53. Al-Khodairy F., Fotou E., Sheldrick K. S., Griffiths D. J. F., Lehmann A. R., Carr A. M. 1994; Identification and characterisation of new elements involved in checkpoints and feedback controls in fission yeast. Mol Biol Cell 5:147–160
     [Google Scholar]
  54. Al-Khodairy F., Enoch T., Hagan I. M., Carr A. M. 1995; The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin- conjugating enzyme required for normal mitosis. J Cell Sci 108:475–486
     [Google Scholar]
  55. Allen J. B., Zhou Z., Siede W., Friedberg E. C., Elledge S. J. 1994; The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev 8:2401–2415
     [Google Scholar]
  56. Barbet N. C., Carr A. M. 1993; Fission yeast weel protein kinase is not required for DNA damage-dependent mitotic arrest. Nature 364:824–827
     [Google Scholar]
  57. Bentley N. J., Holtzman D. A., Flaggs G., Keegan K. S., DeMaggio A., Ford J. C., Hoekstra M., Carr A. M. 1996; The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J 15:6641–6651
     [Google Scholar]
  58. Carr A. M. 1994; Radiation checkpoints in model systems. Int J Radiat Biol 66:S133–S139
     [Google Scholar]
  59. Carr A. M. 1997; Control of cell cycle arrest by the Meclsc/ Rad3sp DNA structure checkpoint pathway. Curr Opitt Genet Dev 7:93–98
     [Google Scholar]
  60. Cimprich K. A., Shin T. B., Keith C. T., Schreiber S. L. 1996; cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci USA 93:2850–2855
     [Google Scholar]
  61. Ellis N. A. 1997; DNA helicases in inherited human disorders. Curr Opin Genet Dev 7:354–363
     [Google Scholar]
  62. Ellis N. A., Groden J., Ye T. -Z., Straughen J., Lennon D. J., Ciocci S., Proytcheva M., German J. 1995; The Bloom’s syndrome gene product is homologous to RecQ helicases. Cell 83:655–666
     [Google Scholar]
  63. Enoch T., Nurse P. 1990; Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60:665–673
     [Google Scholar]
  64. Enoch T., Carr A. M., Nurse P. 1992; Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev 6:2035–2046
     [Google Scholar]
  65. Flaggs G., Plug A. W., Dunks K. M. 9 other authors 1997; ATM- and ATR- dependent interactions of a mammalian CHK1 homolog with meiotic chromosomes. Curr Biol 7:977–986
     [Google Scholar]
  66. Ford J. C., Al-Khodairy F., Fotou E., Sheldrick K. S., Griffiths D. J. F., Carr A. M. 1994; 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Science 265:533–535
     [Google Scholar]
  67. Fumari B., Rhind N., Russell P. 1997; Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science 211:1495–1497
     [Google Scholar]
  68. Griffiths D. J. F., Barbet N. C., McCready S., Lehmann A. R., Carr A. M. 1995; Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J 14:5812–5823
     [Google Scholar]
  69. Hartwell L. H., Kastan M. B. 1994; Cell cycle control and cancer. Science 266:1821–1828
     [Google Scholar]
  70. Jeggo A. P., Taccioli G. E., Jackson S. P. 1995; Menage à trois: double strand break repair, V(D) J recombination and DNA-PK. Bioessays 17:949–957
     [Google Scholar]
  71. Keegan K. S., Holtzman D. A., Plug A. W. 10 other authors 1996; The Atr and Atm protein-kinases associate with different sites along meiotically pairing chromosomes. Genes Dev 10:2423–2437
     [Google Scholar]
  72. Kiser G. L., Weinert T. A. 1996; Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7:703–718
     [Google Scholar]
  73. Kostrub C. F., Al-Khodairy F., Ghazizadeh H., Carr A. M., Enoch T. 1997; Molecular analysis of hus1+, a fission yeast gene required for S-M and DNA damage checkpoints. Mol Gen Genet 254:389–399
     [Google Scholar]
  74. Lehmann A. R. 1996; Molecular biology of DNA repair in the fission yeast Schizosaccharomyces pombe . Mutat Res 363:147–161
     [Google Scholar]
  75. Lindsay H. D., Griffiths D. J. F., Edwards R., Murray J. M., Christensen P. U., Walworth N., Carr A. M. 1998; S-phase specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe . Genes Dev (in press)
    [Google Scholar]
  76. Long K. E., Sunnerhagen P., Subramani S. 1994; The Schizosaccharomyces pombe rad1 gene consists of three exons and the cDNA sequence is partially homologous to the Ustilago maydis REC1 cDNA. Gene 148:155–159
     [Google Scholar]
  77. Lydall D., Nikolsky Y., Bishop D. K., Weinert T. 1996; A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature 383:840–843
     [Google Scholar]
  78. Murakami H., Okayama H. 1995; A kinase from fission yeast responsible for blocking mitosis in S phase. Nature 374:817–819
     [Google Scholar]
  79. Muris D. F. R., Vreeken K., Schmidt H., Ostermann K., Clever B., Lohman P. H. M., Pastink A. 1996; Homologous recombination in the fission yeast Schizosaccharomyces pombe: different requirements for the rhp51+, rhp54+ and rad22+ genes. Curr Genet 31:248–254
     [Google Scholar]
  80. Murray J. M., Carr A. M., Lehmann A. R., Watts F. Z. 1991; Cloning and characterization of the DNA repair gene, rad9, from Schizosaccharomyces pombe . Nucleic Acids Res 19:3525–3531
     [Google Scholar]
  81. Murray J. M., Lindsay H. D., Munday C. A., Carr A. M. 1997; Role of Schizosaccharomyces pombe RecQ homologue, recombination and checkpoint genes in UV damage tolerance. Mol Cell Biol 17: (in press)
    [Google Scholar]
  82. OʹConnell M. J., Raleigh J. M., Verkade H. M., Nurse P. 1997; Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J 16:545–554
     [Google Scholar]
  83. Pati D., Keller C., Groudine M., Plon S. E. 1997; Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Mol Cell Biol 17:3037–3046
     [Google Scholar]
  84. Peng C. -Y., Graves P. R., Thoma R. S., Wu Z., Shaw A. S., Piwnica-Worms H. 1997; Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277:1501–1505
     [Google Scholar]
  85. Rao P. N., Johnson R. T. 1970; Mammalian cell fusion studies on the regulation of DNA synthesis and mitosis. Nature 225:159–164
     [Google Scholar]
  86. Rowley R., Subramani S., Young P. G. 1992; Checkpoint controls in Schizosaccharomyces pombe: radl . EMBO J 11:1335–1342
     [Google Scholar]
  87. Sanchez Y., Desany B. A., Jones W. J., Liu Q., Wang B., Elledge S. J. 1996; Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357–360
     [Google Scholar]
  88. Sanchez Y., Wong C., Thoma R. S., Richman R., Wu Z., Piwnica-Worms H., Elledge S. J. 1997; Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277:1497–1501
     [Google Scholar]
  89. Savitsky K., Bar-Shira A., Gilad S. 27 other authors 1995; A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749–1753
     [Google Scholar]
  90. Sheldrick K. S., Carr A. M. 1993; Feedback controls and G2 checkpoints: fission yeast as a model system. Bioessays 15:775–782
     [Google Scholar]
  91. Stewart E., Chapman C., Al-Khodairy F., Carr A. M., Enoch T. 1997; Rhq1 +, a fission yeast gene related to the Bloom’s and Werner’s syndrome genes, is required for reversible S-phase arrest. EMBO J 16:2682–2692
     [Google Scholar]
  92. Sun Z., Fay D. S., Marini F., Foiani M., Stern D. F. 1996; Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev 10:395–406
     [Google Scholar]
  93. Sunnerhagen P., Seaton B. L., Nasim A., Subramani S. 1990; Cloning and analysis of a gene involved in DNA repair and recombination, the rad1 gene of Schizosaccharomyces pombe . Mol Cell Biol 10:3750–3760
     [Google Scholar]
  94. Taylor E. M., McFarlane R. J., Price C. 1996; 5-Azacytidine treatment of the fission yeast leads to cytotoxicity and cell cycle arrest. Mol Gen Genet 253:128–137
     [Google Scholar]
  95. Thelen M. P., Onel K., Holloman W. K. 1994; The REC1 gene of Ustilago maydis involved in the cellular response to DNA damage encodes an exonuclease. J Biol Chem 269:747–754
     [Google Scholar]
  96. Walworth N., Bernards R. 1996; rad-dependent responses of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271:353–356
     [Google Scholar]
  97. Walworth N., Davey S., Beach D. 1993; Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363:368–371
     [Google Scholar]
  98. Weinert T. A., Hartwell L. H. 1988; The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae . Science 241:317–322
     [Google Scholar]
  99. Weinert T. A., Kiser G. L., Hartwell L. H. 1994; Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8:652–665
     [Google Scholar]
  100. Yu C. -E., Oshima J., Fu Y. -H. 10 other authors 1996; Positional cloning of the Werner’s syndrome gene. Science 272:258–262
     [Google Scholar]
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Analysis of fission yeast DNA structure checkpoints:1996 Fleming Lecture
Microbiology 144, 5 (1998); https://doi.org/10.1099/00221287-144-1-5
/content/journal/micro/10.1099/00221287-144-1-5
/content/journal/micro/10.1099/00221287-144-1-5
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