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Volume 148, Issue 10

Reduced up-regulation of memory and adhesion/integrin molecules in susceptible mice and poor expression of immunity to pulmonary tuberculosis Free

Abstract

Previous studies examining the expression of adhesion and integrin molecules on CD4 T lymphocytes generated in response to virulent infection revealed that certain inbred mouse strains susceptible to breakdown of chronic disease and subsequent reactivation had poor expression of these molecules, which might underlie their inability to adequately focus into lung tissues and mediate protection. The current study examines the possibility that prior vaccination with BCG, or a prior tuberculosis infection, would overcome this deficiency. It was found, however, that this was not the case. Whereas both resistant (C57BL/6) and susceptible (DBA/2, CBA/J) strains were equally well protected in the spleen after intravenous challenge, the latter strains were poorly protected in the lungs regardless of whether the challenge was given by the intravenous or aerosol route. Again, this was associated with poor up-regulation of adhesion and integrin molecules and with histological evidence in memory immune animals of a reduced and delayed influx of T lymphocytes into the lungs.

  • Received:
  • Accepted:
  • Revised:
  • Published Online:
Keyword(s): BCG , Mycobacterium tuberculosis and T cells
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2002-10-01
2024-04-16
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References

  1. Bellamy R, Ruwende C, Corrah T, McAdam K. P, Whittle H. C., Hill A. V. 1998; Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N Engl J Med 338:640–644
     [Google Scholar]
  2. Bellamy R, Beyers N, McAdam K. P. 14 other authors 2000; Genetic susceptibility to tuberculosis in Africans: a genome-wide scan. Proc Natl Acad Sci USA 97:8005–8009
     [Google Scholar]
  3. Bloom B. R., Murray C. J. 1992; Tuberculosis: commentary on a reemergent killer. Science 257:1055–1064
     [Google Scholar]
  4. D’Souza C. D, Cooper A. M, Frank A. A, Ehlers S, Turner J, Bendelac A., Orme I. M. 2000; A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. Am J Respir Cell Mol Biol 23:188–193
     [Google Scholar]
  5. Dannenberg A. M. Jr 1994; Roles of cytotoxic delayed-type hypersensitivity and macrophage-activating cell-mediated immunity in the pathogenesis of tuberculosis. Immunobiology 191:461–473
     [Google Scholar]
  6. Dye C, Scheele S, Dolin P, Pathania V., Raviglione M. C. 1999; Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA (J Am Med Assoc) 282:677–686
     [Google Scholar]
  7. Fine P. E, Ponnighaus J. M, Maine N, Clarkson J. A., Bliss L. 1986; Protective efficacy of BCG against leprosy in Northern Malawi. Lancet 2:499–502
     [Google Scholar]
  8. Flynn J. L, Goldstein M. M, Triebold K. J, Koller B., Bloom B. R. 1992; Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA 89:12013–12017
     [Google Scholar]
  9. Gros P, Skamene E., Forget A. 1981; Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J Immunol 127:2417–2421
     [Google Scholar]
  10. Horsburgh C. R. Jr 2000; The global problem of multidrug-resistant tuberculosis: the genie is out of the bottle. JAMA (J Am Med Assoc) 283:2575–2576
     [Google Scholar]
  11. Lillebaek T, Andersen A. B, Bauer J, Dirksen A, Glismann S, de Haas P., Kok-Jensen A. 2001; Risk of Mycobacterium tuberculosis transmission in a low-incidence country due to immigration from high-incidence areas. J Clin Microbiol 39:855–861
     [Google Scholar]
  12. Medina E., North R. J. 1996; Evidence inconsistent with a role for the Bcg gene ( Nramp1 ) in resistance of mice to infection with virulent Mycobacterium tuberculosis . J Exp Med 183:1045–1051
     [Google Scholar]
  13. Medina E., North R. J. 1998; Resistance ranking of some common inbred mouse strains to Mycobacterium tuberculosis and relationship to major histocompatibility complex haplotype and Nramp1 genotype. Immunology 93:270–274
     [Google Scholar]
  14. Netto E. M, Dye C., Raviglione M. C. 1999; Progress in global tuberculosis control 1995–1996, with emphasis on 22 high-incidence countries. Global Monitoring and Surveillance Project. Int J Tuberc Lung Dis 3:310–320
     [Google Scholar]
  15. Orme I. M. 1988; Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection. J Immunol 140:3589–3593
     [Google Scholar]
  16. Orme I. M, Miller E. S, Roberts A. D, Furney S. K, Griffin J. P, Dobos K. M, Chi D, Rivoire B., Brennan P. J. 1992; T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens. J Immunol 148:189–196
     [Google Scholar]
  17. Serbina N. V., Flynn J. L. 1999; Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis -infected mice. Infect Immun 67:3980–3988
     [Google Scholar]
  18. Shaw M. A, Collins A, Peacock C. S. 7 other authors 1997; Evidence that genetic susceptibility to Mycobacterium tuberculosis in a Brazilian population is under oligogenic control: linkage study of the candidate genes NRAMP1 and TNFA . Tuber Lung Dis 78:35–45
     [Google Scholar]
  19. Stead W. W, Senner J. W, Reddick W. T., Lofgren J. P. 1990; Racial differences in susceptibility to infection by Mycobacterium tuberculosis . N Engl J Med 322:422–427
     [Google Scholar]
  20. Turner J, Gonzalez-Juarrero M, Saunders B. M, Brooks J. V, Marietta P, Ellis D. L, Frank A. A, Cooper A. M., Orme I. M. 2001a; Immunological basis for reactivation of tuberculosis in mice. Infect Immun 69:3264–3270
     [Google Scholar]
  21. Turner J, D’Souza C. D, Pearl J. E, Marietta P, Noel M, Frank A. A, Appelberg R, Orme I. M., Cooper A. M. 2001b; CD8-and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis. Am J Respir Cell Mol Biol 24:203–209
     [Google Scholar]
  22. Vidal S, Tremblay M. L, Govoni G. 7 other authors 1995; The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med 182:655–666
     [Google Scholar]
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Reduced up-regulation of memory and adhesion/integrin molecules in susceptible mice and poor expression of immunity to pulmonary tuberculosis
Microbiology 148, 2959 (2002); https://doi.org/10.1099/00221287-148-10-2959
/content/journal/micro/10.1099/00221287-148-10-2959
/content/journal/micro/10.1099/00221287-148-10-2959
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