The Fixation of Tetanus Toxin by GanĒµlioside Van Heyningen, W. E. and Miller, Pauline Allan,, 24, 107-119 (1961), doi = https://doi.org/10.1099/00221287-24-1-107, publicationName = Microbiology Society, issn = 1350-0872, abstract= SUMMARY: The fixation of tetanus toxin by brain ganglioside has been confirmed. A method has been developed for assaying the toxin-fixing capacity of ganglioside in the analytical ultracentrifuge. Under appropriate conditions ganglioside will fix many times its own weight of toxin. Ganglioside preparations from brain contain at least three gangliosides; at least two of these differ in their sialic acid contents and toxinfixing capacities. The sialic acid residues (and their free carboxyl groups) are essential for toxin-fixation. Tetanus toxin does not appear (so far) to bring about any change in the ganglioside molecule., language=, type=