RT Journal Article SR Electronic(1) A1 van Heyningen, W. E. A1 Mellanby, JaneYR 1968 T1 The Effect of Cerebroside and Other Lipids on the Fixation of Tetanus Toxin by Gangliosides JF Microbiology, VO 52 IS 3 SP 447 OP 454 DO https://doi.org/10.1099/00221287-52-3-447 PB Microbiology Society, SN 1465-2080, AB SUMMARY: Water-insoluble complexes of ganglioside with cerebroside fixed tetanus toxin at low concentrations (a few LD 50/ml.) of toxin. A complex containing 25% ganglioside with cerebroside was 50 times better at fixing toxin than complexes containing either 2% or 50% ganglioside. A complex containing 25% of a mixture of the gangliosides Giii and Giv was 12 times better at fixing toxin than a similar complex with gangliosides Gi and GII. Complexes of ganglioside with sphingomyelin and lecithin fixed toxin to a slight extent, while complexes with tripalmitin and cholesterol did not fix toxin. The complex of cerebroside and ganglioside, containing 25% ganglioside, did not fix strychnine, serotonin, botulinum toxin or plasma albumin., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-52-3-447