1887

Abstract

SUMMARY: In four out of five strains of examined, genes determining fusidic acid resistance were associated with a penicillinase plasmid. In one strain (FAR5), although the linkage was unstable, resistance to fusidic acid was co-transduced with resistance to cadmium ions and penicillinase production. Further evidence for a single plasmid in this strain was obtained by studying the physical nature of the plasmid DNA. The molecular weight of the entire linkage group was about 16 million daltons; the molecular weight of the residual plasmid after loss of fusidic acid resistance was about 15 million.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-73-3-501
1972-12-01
2024-04-18
Loading full text...

Full text loading...

/deliver/fulltext/micro/73/3/mic-73-3-501.html?itemId=/content/journal/micro/10.1099/00221287-73-3-501&mimeType=html&fmt=ahah

References

  1. Annear D. I., Grubb W. B. 1972; Linked and unstable resistance to kanamycin and penicillin, and diffusible pigment production in an isolate of Staphylococcus aureus . Journal of Medical Microbiology 5:109–111
    [Google Scholar]
  2. Arber W. 1960; Transduction of chromosomal genes and episomes in Escherichia coli . Virology 11:273–288
    [Google Scholar]
  3. Asheshov E. H. 1966; Chromosomal location of the genetic elements controlling penicillinase production in a strain of Staphylococcus aureus . Nature, London 210:804–806
    [Google Scholar]
  4. Dyke K. G. H., Jevons M. P., Parker M. T. 1966; Penicillinase production and intrinsic resistance to penicillins in Staphylococcus aureus . Lancet i:835–837
    [Google Scholar]
  5. Dyke K. G. H., Parker M. T., Richmond M. H. 1970; Penicillinase production and metal-ion resistance in Staphylococcus aureus isolated from hospital patients. Journal of Medical Microbiology 3:125–136
    [Google Scholar]
  6. Evans R. J., Waterworth P. M. 1966; Naturally-occurring fusidic acid resistance in staphylococci and its linkage to other resistances. Journal of Clinical Pathology 19:555–560
    [Google Scholar]
  7. Grinsted J., Saunders J. R., Ingram L. C., Sykes R. B., Richmond M. H. 1972; Properties of an R-factor which originated in Pseudomonas aeruginosa 1822. Journal of Bacteriology 110:529–537
    [Google Scholar]
  8. Lacey R. W. 1971; Transfer of tetracycline-resistance between strains of Staphylococcus aureus in mixed cultures. Journal of General Microbiology 69:229–237
    [Google Scholar]
  9. Mitsuhashi S., Hashimoto H., Kono M., Morimura M. 1965; Drug resistance of staphylococci. II. Joint elimination and joint transduction of the determinants of penicillinase production and resistance to macrolide antibiotics. Journal of Bacteriology 89:988–996
    [Google Scholar]
  10. Novick R. P., Bouanchaud D. 1971; Extrachromosomal nature of drug resistance in Staphylococcus aureus . Annals of the New York Academy of Sciences 182:279–294
    [Google Scholar]
  11. Richmond M. H. 1967; Associated diploids involving penicillinase plasmids in Staphylococcus aureus . Journal of General Microbiology 46:85–93
    [Google Scholar]
  12. Richmond M. H. 1969; Extrachromosomal elements and the spread of antibiotic resistance in bacteria. Biochemical Journal 113:225–234
    [Google Scholar]
  13. Rush M. G., Gordon C. N., Novick R. P., Warner R. C. 1969; Penicillinase plasmid DNA from Staphylococcus aureus . Proceedings of the National Academy of Sciences of the United States of America, 63:1304–1310
    [Google Scholar]
  14. Studier F. W. 1965; Sedimentation studies of size and shape of DNA. Journal of Molecular Biology 11:373–390
    [Google Scholar]
  15. Vinograd S., Lebowitz S., Radloff R., Watson R., Laipis P. 1965; The twisted circular form of polyoma viral DNA. Proceedings of the National Academy of Sciences of the United States of America, S3:1104–1111
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-73-3-501
Loading
/content/journal/micro/10.1099/00221287-73-3-501
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error