f Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina
- Authors: Gary A. Strobel, R. Vincent Miller, Concepcion Martinez-Miller, Margaret M. Condron, David B. Teplow, W. M. Hess
- Author for correspondence: Gary A. Strobel. Tel: + 1 406 994 5148. Fax: + 1 406 994 1848. e-mail: firstname.lastname@example.org
- Microbiology, August 1999 145: 1919-1926, doi: 10.1099/13500872-145-8-1919
- Subject: Biochemistry
- Published Online:
A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular mass of 1079 Da, contains equimolar amounts of 3,4-dihydroxyhomotyrosine, 4-hydroxyproline, threonine, glutamine, 3-hydroxy-4-hydroxymethylproline, 4,5-dihydroxyornithine and palmitic acid. Cryptocandin is chemically related to well-known antimycotics, the echinocandins and pneumocandins, which are produced by such fungi as Zalerion arboricola, Pezicula spp. and Aspergillus spp. Cryptocandin has minimal inhibitory concentration values of 0-03-0-07 μg ml-1 against isolates of Candida albicans, Trichophyton mentagrophytes and Trichophyton rubrum. Cryptocandin is also active against a number of plant-pathogenic fungi including Sclerotinia sclerotiorum and Botrytis cinerea.
Abbreviation: DMT, 4,4-dimethoxytrityl chloride.
© Society for General Microbiology | Published by the Microbiology Society
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