%0 Journal Article %A Gally, David L. %A Stevens, Mark P. %T Microbe Profile: Escherichia coli O157 : H7 – notorious relative of the microbiologist’s workhorse %D 2017 %J Microbiology, %V 163 %N 1 %P 1-3 %@ 1465-2080 %R https://doi.org/10.1099/mic.0.000387 %K type 3 secretion %K Shiga toxin %K E. coli O157 %K bacteriophage %K cattle %I Microbiology Society, %X Escherichia coli O157 : H7 is a zoonotic diarrhoeal pathogen of worldwide importance. It belongs to a subset of Shiga toxin-producing E. coli that can form attaching and effacing lesions on intestinal epithelia via the action of a type 3 secretion system that injects bacterial effectors into enterocytes. Infections in humans often arise from contaminated food or direct environmental exposure and can involve life-threatening Shiga toxin-dependent sequelae. In the three decades since E. coli O157 : H7 was first recognized intensive research has helped to unravel the basis of pathogenesis, but few effective options for prevention and treatment of infections exist. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000387