RT Journal Article SR Electronic(1) A1 Eder, Adrianna E. A1 Munir, Saba A. A1 Hobby, Chelsea R. A1 Anderson, Derek M. A1 Herndon, Joshua L. A1 Siv, Andrew W. A1 Symes, Steven J. K. A1 Giles, David K.YR 2017 T1 Exogenous polyunsaturated fatty acids (PUFAs) alter phospholipid composition, membrane permeability, biofilm formation and motility in Acinetobacter baumannii JF Microbiology, VO 163 IS 11 SP 1626 OP 1636 DO https://doi.org/10.1099/mic.0.000556 PB Microbiology Society, SN 1465-2080, AB Acinetobacter baumannii is a ubiquitous multidrug-resistant bacteria that is found on a variety of surfaces, including skin, hair and soil. During the past decade, A. baumannii has emerged as a significant cause of nosocomial infections in the United States. Recent studies have highlighted the ability of some bacteria to utilize a wide variety of fatty acids as a membrane remodelling strategy. Considering this, we hypothesized that fatty acids may have an effect on the emerging pathogen A. baumannii. Thin-layer chromatography indicated structural alterations to major phospholipids. Liquid chromatography/mass spectrometry confirmed the assimilation of numerous exogenous polyunsaturated fatty acids (PUFAs) into the phospholipid species of A. baumannii. The incorporation of fatty acids affected several bacterial phenotypes, including membrane permeability, biofilm formation, surface motility and antimicrobial peptide resistance., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000556