Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe Gordon, Stephen V. and Parish, Tanya,, 164, 437-439 (2018), doi = https://doi.org/10.1099/mic.0.000601, publicationName = Microbiology Society, issn = 1350-0872, abstract= Mycobacterium tuberculosis is an expert and deadly pathogen, causing the disease tuberculosis (TB) in humans. It has several notable features: the ability to enter non-replicating states for long periods and cause latent infection; metabolic remodelling during chronic infection; a thick, waxy cell wall; slow growth rate in culture; and intrinsic drug resistance and antibiotic tolerance. As a pathogen, M. tuberculosis has a complex relationship with its host, is able to replicate inside macrophages, and expresses diverse immunomodulatory molecules. M. tuberculosis currently causes over 1.8 million deaths a year, making it the world’s most deadly human pathogen., language=, type=