RT Journal Article SR Electronic(1) A1 Steyaert, Johanna M. A1 Weld, Richard J. A1 Mendoza-Mendoza, Artemio A1 Stewart, AlisonYR 2010 T1 Reproduction without sex: conidiation in the filamentous fungus Trichoderma JF Microbiology, VO 156 IS 10 SP 2887 OP 2900 DO https://doi.org/10.1099/mic.0.041715-0 PB Microbiology Society, SN 1465-2080, AB Trichoderma spp. have served as models for asexual reproduction in filamentous fungi for over 50 years. Physical stimuli, such as light exposure and mechanical injury to the mycelium, trigger conidiation; however, conidiogenesis itself is a holistic response determined by the cell's metabolic state, as influenced by the environment and endogenous biological rhythms. Key environmental parameters are the carbon and nitrogen status and the C : N ratio, the ambient pH and the level of calcium ions. Recent advances in our understanding of the molecular biology of this fungus have revealed a conserved mechanism of environmental perception through the White Collar orthologues BLR-1 and BLR-2. Also implicated in the molecular regulation are the PacC pathways and the conidial regulator VELVET. Signal transduction cascades which link environmental signals to physiological outputs have also been revealed., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.041715-0