The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis

References

1. Bibb M. J. ( 2005). Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol 8:208–215 [View Article][PubMed]
   [Google Scholar]
2. Bierman M., Logan R., O’Brien K., Seno E. T., Rao R. N., Schoner B. E. ( 1992). Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116:43–49 [View Article][PubMed]
   [Google Scholar]
3. Bunet R., Mendes M. V., Rouhier N., Pang X., Hotel L., Leblond P., Aigle B. ( 2008). Regulation of the synthesis of the angucyclinone antibiotic alpomycin in Streptomyces ambofaciens by the autoregulator receptor AlpZ and its specific ligand. J Bacteriol 190:3293–3305 [View Article][PubMed]
   [Google Scholar]
4. Bunet R., Song L., Mendes M. V., Corre C., Hotel L., Rouhier N., Framboisier X., Leblond P., Challis G. L., Aigle B. ( 2011). Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins. J Bacteriol 193:1142–1153 [View Article][PubMed]
   [Google Scholar]
5. Burg R. W., Miller B. M., Baker E. E., Birnbaum J., Currie S. A., Hartman R., Kong Y. L., Monaghan R. L., Olson G. et al. ( 1979). Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob Agents Chemother 15:361–367[PubMed] [CrossRef]
   [Google Scholar]
6. Cundliffe E. ( 2008). Control of tylosin biosynthesis in Streptomyces fradiae . J Microbiol Biotechnol 18:1485–1491[PubMed]
   [Google Scholar]
7. de Jong W., Wösten H. A., Dijkhuizen L., Claessen D. ( 2009). Attachment of Streptomyces coelicolor is mediated by amyloidal fimbriae that are anchored to the cell surface via cellulose. Mol Microbiol 73:1128–1140 [View Article][PubMed]
   [Google Scholar]
8. Folcher M., Gaillard H., Nguyen L. T., Nguyen K. T., Lacroix P., Bamas-Jacques N., Rinkel M., Thompson C. J. ( 2001). Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase. J Biol Chem 276:44297–44306 [View Article][PubMed]
   [Google Scholar]
9. Gottelt M., Kol S., Gomez-Escribano J. P., Bibb M., Takano E. ( 2010). Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2). Microbiology 156:2343–2353 [View Article][PubMed]
   [Google Scholar]
10. Healy F. G., Eaton K. P., Limsirichai P., Aldrich J. F., Plowman A. K., King R. R. ( 2009). Characterization of γ-butyrolactone autoregulatory signaling gene homologs in the angucyclinone polyketide WS5995B producer Streptomyces acidiscabies . J Bacteriol 191:4786–4797 [View Article][PubMed]
    [Google Scholar]
11. Horinouchi S. ( 2007). Mining and polishing of the treasure trove in the bacterial genus Streptomyces . Biosci Biotechnol Biochem 71:283–299 [View Article][PubMed]
    [Google Scholar]
12. Ikeda H., Kotaki H., Omura S. ( 1987). Genetic studies of avermectin biosynthesis in Streptomyces avermitilis . J Bacteriol 169:5615–5621[PubMed]
    [Google Scholar]
13. Ikeda H., Nonomiya T., Usami M., Ohta T., Omura S. ( 1999). Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis . Proc Natl Acad Sci U S A 96:9509–9514 [View Article][PubMed]
    [Google Scholar]
14. Ishikawa J., Hotta K. ( 1999). FramePlot: a new implementation of the frame analysis for predicting protein-coding regions in bacterial DNA with a high G + C content. FEMS Microbiol Lett 174:251–253 [View Article][PubMed]
    [Google Scholar]
15. Kang J. G., Hahn M. Y., Ishihama A., Roe J. H. ( 1997). Identification of sigma factors for growth phase-related promoter selectivity of RNA polymerases from Streptomyces coelicolor A3(2). Nucleic Acids Res 25:2566–2573 [View Article][PubMed]
    [Google Scholar]
16. Kawamoto S., Watanabe H., Hesketh A., Ensign J. C., Ochi K. ( 1997). Expression analysis of the ssgA gene product, associated with sporulation and cell division in Streptomyces griseus . Microbiology 143:1077–1086 [View Article][PubMed]
    [Google Scholar]
17. Kieser T., Bibb M. J., Buttner M. J., Chater K. F., Hopwood D. A. ( 2000). Practical Streptomyces Genetics Norwich: John Innes Foundation;
    [Google Scholar]
18. Kinoshita H., Ipposhi H., Okamoto S., Nakano H., Nihira T., Yamada Y. ( 1997). Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae . J Bacteriol 179:6986–6993[PubMed]
    [Google Scholar]
19. Kitani S., Ikeda H., Sakamoto T., Noguchi S., Nihira T. ( 2009). Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis . Appl Microbiol Biotechnol 82:1089–1096 [View Article][PubMed]
    [Google Scholar]
20. Komatsu M., Uchiyama T., Omura S., Cane D. E., Ikeda H. ( 2010). Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci U S A 107:2646–2651 [View Article][PubMed]
    [Google Scholar]
21. Lamb D. C., Ikeda H., Nelson D. R., Ishikawa J., Skaug T., Jackson C., Omura S., Waterman M. R., Kelly S. L. ( 2003). Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochem Biophys Res Commun 307:610–619 [View Article][PubMed]
    [Google Scholar]
22. López-García M. T., Santamarta I., Liras P. ( 2010). Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant. Microbiology 156:2354–2365 [View Article][PubMed]
    [Google Scholar]
23. Matsuno K., Yamada Y., Lee C. K., Nihira T. ( 2004). Identification by gene deletion analysis of barB as a negative regulator controlling an early process of virginiamycin biosynthesis in Streptomyces virginiae . Arch Microbiol 181:52–59 [View Article][PubMed]
    [Google Scholar]
24. Nakano H., Lee C. K., Nihira T., Yamada Y. ( 2000). A null mutant of the Streptomyces virginiae barA gene encoding a butyrolactone autoregulator receptor and its phenotypic and transcriptional analysis. J Biosci Bioeng 90:204–207[PubMed] [CrossRef]
    [Google Scholar]
25. Natsume R., Ohnishi Y., Senda T., Horinouchi S. ( 2004). Crystal structure of a γ-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2). J Mol Biol 336:409–419 [View Article][PubMed]
    [Google Scholar]
26. Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H. et al. ( 2001). Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A 98:12215–12220 [View Article][PubMed]
    [Google Scholar]
27. Pan Y., Liu G., Yang H., Tian Y., Tan H. ( 2009). The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes . Mol Microbiol 72:710–723 [View Article][PubMed]
    [Google Scholar]
28. Pulsawat N., Kitani S., Nihira T. ( 2007). Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae . Gene 393:31–42 [View Article][PubMed]
    [Google Scholar]
29. Pulsawat N., Kitani S., Fukushima E., Nihira T. ( 2009). Hierarchical control of virginiamycin production in Streptomyces virginiae by three pathway-specific regulators: VmsS, VmsT and VmsR. Microbiology 155:1250–1259 [View Article][PubMed]
    [Google Scholar]
30. Strohl W. R. ( 1992). Compilation and analysis of DNA sequences associated with apparent streptomycete promoters. Nucleic Acids Res 20:961–974 [View Article][PubMed]
    [Google Scholar]
31. Takano E. ( 2006). γ-Butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation. Curr Opin Microbiol 9:287–294 [View Article][PubMed]
    [Google Scholar]
32. Takano E., Kinoshita H., Mersinias V., Bucca G., Hotchkiss G., Nihira T., Smith C. P., Bibb M., Wohlleben W., Chater K. ( 2005). A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor . Mol Microbiol 56:465–479 [View Article][PubMed]
    [Google Scholar]
33. Traag B. A., van Wezel G. P. ( 2008). The SsgA-like proteins in actinomycetes: small proteins up to a big task. Antonie van Leeuwenhoek 94:85–97 [View Article][PubMed]
    [Google Scholar]
34. van Wezel G. P., van der Meulen J., Kawamoto S., Luiten R. G., Koerten H. K., Kraal B. ( 2000). ssgA is essential for sporulation of Streptomyces coelicolor A3(2) and affects hyphal development by stimulating septum formation. J Bacteriol 182:5653–5662 [View Article][PubMed]
    [Google Scholar]
35. Wei X., Yunxiang L., Yinghua Z. ( 2006). Enhancement and selective production of oligomycin through inactivation of avermectin’s starter unit in Streptomyces avermitilis . Biotechnol Lett 28:911–916 [View Article][PubMed]
    [Google Scholar]
36. Xu H., Chater K. F., Deng Z., Tao M. ( 2008). A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in streptomyces. J Bacteriol 190:4971–4978 [View Article][PubMed]
    [Google Scholar]