Bacterial chitinases and chitin-binding proteins as virulence factors
Frederiksen, Rikki F. and Paspaliari, Dafni K. and Larsen, Tanja and Storgaard, Birgit G. and Larsen, Marianne H. and Ingmer, Hanne and Palcic, Monica M. and Leisner, Jørgen J.,, 159, 833-847 (2013),
doi = https://doi.org/10.1099/mic.0.051839-0,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.,
language=,
type=