RT Journal Article SR Electronic(1) A1 Mac Aogáin, M. A1 Mooij, M. J. A1 McCarthy, R. R. A1 Plower, E. A1 Wang, Y. P. A1 Tian, Z. X. A1 Dobson, A. A1 Morrissey, J. A1 Adams, C. A1 O’Gara, F.YR 2012 T1 The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa JF Microbiology, VO 158 IS 10 SP 2598 OP 2609 DO https://doi.org/10.1099/mic.0.058636-0 PB Microbiology Society, SN 1465-2080, AB PyeR (PA4354) is a novel member of the ArsR family of transcriptional regulators and modulates biofilm formation in Pseudomonas aeruginosa. Characterization of this regulator showed that it has negative autoregulatory properties and binds to a palindromic motif conserved among PyeR orthologues. These characteristics are in line with classical ArsR-family regulators, as is the fact that PyeR is part of an operon structure (pyeR-pyeM-xenB). However, PyeR also exhibits some atypical features in comparison with classical members of the ArsR family, as it does not harbour metal-binding motifs and does not appear to be involved in metal perception or resistance. Hence, PyeR belongs to a subgroup of non-classical ArsR-family regulators and is the second ArsR regulator shown to be involved in biofilm formation., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.058636-0