1887

Abstract

Hha-like proteins are an evolutive trait of members of the family . These proteins mimic the oligomerization domain of the nucleoid-associated protein H-NS and interact with this latter protein to modulate gene expression. In this report, we provide evidence that, as has been shown for H-NS, Hha-like proteins play an essential role facilitating acquisition of horizontally transferred DNA in both and . Incorporation of conjugative plasmids such as pHly152 or R27 results in a fitness cost in or strains that lack Hha-like proteins. spontaneous derivatives from double mutants that showed an increased growth rate and a restored fitness overexpressed the H-NS protein. In addition to reinforcing the role of H-NS/Hha-modulating xenogeneic DNA, the results obtained demonstrate that the display regulatory features not found in other bacteria that facilitate incorporation of horizontally transferred DNA.

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2013-03-01
2024-03-28
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