%0 Journal Article %A Maddocks, Sarah E. %A Oyston, Petra C. F. %T Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins %D 2008 %J Microbiology, %V 154 %N 12 %P 3609-3623 %@ 1465-2080 %R https://doi.org/10.1099/mic.0.2008/022772-0 %K LTTR, LysR-type transcriptional regulator %K wHTH, winged-HTH %K HTH, helix–turn–helix %K ABS, activation binding site %K RBS, regulatory binding site %K DBD, DNA-binding domain %I Microbiology Society, %X The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom. Members of this family have a conserved structure with an N-terminal DNA-binding helix–turn–helix motif and a C-terminal co-inducer-binding domain. Despite considerable conservation both structurally and functionally, LysR-type transcriptional regulators (LTTRs) regulate a diverse set of genes, including those involved in virulence, metabolism, quorum sensing and motility. Numerous structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.2008/022772-0