Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins Maddocks, Sarah E. and Oyston, Petra C. F.,, 154, 3609-3623 (2008), doi = https://doi.org/10.1099/mic.0.2008/022772-0, publicationName = Microbiology Society, issn = 1350-0872, abstract= The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom. Members of this family have a conserved structure with an N-terminal DNA-binding helix–turn–helix motif and a C-terminal co-inducer-binding domain. Despite considerable conservation both structurally and functionally, LysR-type transcriptional regulators (LTTRs) regulate a diverse set of genes, including those involved in virulence, metabolism, quorum sensing and motility. Numerous structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators., language=, type=