Correlation of the rate of protein synthesis and the third power of the RNA : protein ratio in Escherichia coli and Mycobacterium tuberculosis
Cox, Robert A.,, 149, 729-737 (2003),
doi = https://doi.org/10.1099/mic.0.25645-0,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= In order to further understand the different physiological states of the tubercle bacillus, a frame of reference was sought by first correlating the macromolecular compositions of Escherichia coli with specific growth rates and also with the rates of protein synthesis. Data for DNA : protein : RNA were converted to the average amounts of DNA [ m DNA(av)], protein [ m p(av)] and RNA [ m RNA(av)] per cell. The specific growth rate μ was found to be directly proportional to m RNA(av)/ m p(av). The specific protein synthesis rate per average cell [ω p(av)] was shown to be directly proportional to the third power of the ratio m RNA(av)/ m p(av) which reflects the ribosome concentration. The equations derived were shown apply to both E. coli (μ=1·73 h−1) and Mycobacterium bovis BCG (μ=0·029 h−1).,
language=,
type=