RT Journal Article SR Electronic(1) A1 Ezra, David A1 Castillo, Uvidelio F. A1 Strobel, Gary A. A1 Hess, Wilford M. A1 Porter, Heidi A1 Jensen, James B. A1 Condron, Margaret A. M. A1 Teplow, David B. A1 Sears, Joseph A1 Maranta, Michelle A1 Hunter, Michelle A1 Weber, Barbara A1 Yaver, DebbieYR 2004 T1 Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp. JF Microbiology, VO 150 IS 4 SP 785 OP 793 DO https://doi.org/10.1099/mic.0.26645-0 PB Microbiology Society, SN 1465-2080, AB Coronamycin is a complex of novel peptide antibiotics with activity against pythiaceous fungi and the human fungal pathogen Cryptococcus neoformans. It is also active against the malarial parasite, Plasmodium falciparum, with an IC50 of 9·0 ng ml−1. Coronamycin is produced by a verticillate Streptomyces sp. isolated as an endophyte from an epiphytic vine, Monstera sp., found in the Manu region of the upper Amazon of Peru. Bioassay-guided fractionation of the fermentation broths of this endophyte on silica gel and HPLC chromatography yielded two principal, inseparable, peptides with masses of 1217·9 and 1203·8 Da. Three other minor, but related components, are also present in the preparation. Amino acid analysis of coronamycin revealed residues of component 1, component 2, methionine, tyrosine and leucine at a ratio of 2 : 2 : 1 : 1 : 3. Other compounds with antifungal activities are also produced by this endophytic streptomycete., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.26645-0