%0 Journal Article %A Fehr, Désirée %A Casanova, Carlo %A Liverman, Amy %A Blazkova, Hana %A Orth, Kim %A Dobbelaere, Dirk %A Frey, Joachim %A Burr, Sarah E. %T AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway %D 2006 %J Microbiology, %V 152 %N 9 %P 2809-2818 %@ 1465-2080 %R https://doi.org/10.1099/mic.0.28889-0 %K ERK, extracellular signal-regulated kinase %K TNF-α, tumour necrosis factor alpha %K IKK, IκB kinase %K MAPK, mitogen-activated protein kinase %K NF-κB, nuclear factor kappa B %K TTSS, type three secretion system %K wt, wild-type %K EGF, epidermal growth factor %K MKK, MAPK kinase %K HA, haemagglutinin %I Microbiology Society, %X Aeromonas salmonicida subsp. salmonicida contains a functional type III secretion system that is responsible for the secretion of the ADP-ribosylating toxin AexT. In this study, the authors identified AopP as a second effector protein secreted by this system. The aopP gene was detected in both typical and atypical A. salmonicida isolates and was found to be encoded on a small plasmid of approximately 6.4 kb. Sequence analysis indicates that AopP is a member of the YopJ family of effector proteins, a group of proteins that interfere with mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa B (NF-κB) signalling pathways. AopP inhibits the NF-κB pathway downstream of IκB kinase (IKK) activation, while a catalytically inactivated mutant, AopPC177A, does not possess this inhibitory effect. Unlike other effectors of the YopJ family, such as YopJ and VopA, AopP does not inhibit the MAPK signalling pathway. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.28889-0