RT Journal Article SR Electronic(1) A1 Fehr, Désirée A1 Casanova, Carlo A1 Liverman, Amy A1 Blazkova, Hana A1 Orth, Kim A1 Dobbelaere, Dirk A1 Frey, Joachim A1 Burr, Sarah E.YR 2006 T1 AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway JF Microbiology, VO 152 IS 9 SP 2809 OP 2818 DO https://doi.org/10.1099/mic.0.28889-0 PB Microbiology Society, SN 1465-2080, AB Aeromonas salmonicida subsp. salmonicida contains a functional type III secretion system that is responsible for the secretion of the ADP-ribosylating toxin AexT. In this study, the authors identified AopP as a second effector protein secreted by this system. The aopP gene was detected in both typical and atypical A. salmonicida isolates and was found to be encoded on a small plasmid of approximately 6.4 kb. Sequence analysis indicates that AopP is a member of the YopJ family of effector proteins, a group of proteins that interfere with mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa B (NF-κB) signalling pathways. AopP inhibits the NF-κB pathway downstream of IκB kinase (IKK) activation, while a catalytically inactivated mutant, AopPC177A, does not possess this inhibitory effect. Unlike other effectors of the YopJ family, such as YopJ and VopA, AopP does not inhibit the MAPK signalling pathway., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.28889-0