Soil-dwelling streptomycete bacteria produce the majority of antibiotics used clinically. In the face of rising antibiotic resistance and re-isolation of known compounds from well-studied traditional antibiotic producers, new sources of chemical inspiration are urgently needed. The ocean remains a largely underexplored habitat with a wealth of bacteria to discover. We sought to explore, through whole genome sequencing, the biosynthetic potential of the understudied rare marine actinomycetes. These close cousins of the prolific streptomycetes are an untapped reservoir of novel biosynthetic gene clusters and a valuable resource in the quest for new bioactive molecules.