1887

Abstract

Multiple bacterial species often coexist as communities, and compete for environmental resources. Here, we describe how an opportunistic pathogen, , uses extracellular products to interact with the nosocomial pathogen . biofilms and planktonic cultures were challenged with supernatant cultures overnight. Results indicated that quorum-sensing-controlled factors from supernatant inhibited growth in planktonic cultures. We also found that extracellular products, mainly polysaccharides, disrupted established biofilms. Cellulase-treated supernatant, and supernatant from , and mutants, which are deficient in polysaccharide biosynthesis, diminished the disruption of biofilms. In contrast, supernatant in overnight cultures had no effect on established biofilms and planktonic growth. These findings reveal that extracellular products are important microbial competition factors that overcome competition with , and the results may provide clues for the development of a novel strategy for controlling biofilms.

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2009-07-01
2024-03-29
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