1887

Abstract

Summary

The antimicrobial drug 1-methyl-2-nitro-5-vinylimidazole (MEV) preferentially blocked DNA synthesis, was mutagenic and induced coliphage λ in The antibacterial effects of MEV are the consequences of repairable damage to DNA, as shown by hypersensitivity of and strains to MEV and related drugs, stimulation by MEV of DNA turnover which was dependent on the product of the gene, and the presence of cross-links in DNA from MEV-treated bacteria.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-100-2-271
1977-06-01
2024-04-28
Loading full text...

Full text loading...

/deliver/fulltext/micro/100/2/mic-100-2-271.html?itemId=/content/journal/micro/10.1099/00221287-100-2-271&mimeType=html&fmt=ahah

References

  1. Adams M. H. 1959 Bacteriophages New York: Interscience (Wiley);
    [Google Scholar]
  2. Austin S. J., Tittawella I. P. B., Hayward R. S., Scaife J. G. 1971; Amber mutations of Escherichia coli RNA polymerase. Nature New Biology 232:133–136
    [Google Scholar]
  3. Bautz Freese E., Gerson J., Taber H., Rhaese H. J., Freese E. 1967; Inactivating DNA alterations induced by peroxides and peroxide-producing agents. Mutation Research 4:517–531
    [Google Scholar]
  4. Braun A., Grossman L. 1974; An endonuclease from Escherichia coli that acts preferentially on UV- irradiated DNA and is absent from the uvrA and uvrB mutants. Proceedings of the National Academy of Sciences of the United States of America 711838–1842
    [Google Scholar]
  5. Cavalleri B., Ballotta R., Lancini G. C. 1972; Synthesis of I-alkyl-2-nitroimidazole-5-carboxalde- hydes. Journal of Heterocyclic Chemistry 9:979–984
    [Google Scholar]
  6. Cavalleri B., Ballotta R., Arioli V., Lancini G. C. 1973; News-substituted I-alkyl-2-nitroimida- zoles. Journal of Medicinal Chemistry 15:557–560
    [Google Scholar]
  7. Clark A. J., Chamberlin M., Boyce R. P., Howard-Flanders P. 1966; Abnormal metabolic re�sponse to ultraviolet light of a recombination deficient mutant of Escherichia coli KI2. Journal of Molecular Biology 19:442–454
    [Google Scholar]
  8. Dann O., Möller E. F. 1947; Bakteriostatisch wirkende Nitro-Verbindungen des Thiophens und Furans. Chemische Berichte 80:23–36
    [Google Scholar]
  9. Davis B. D., Mingioli E. S. 1950; Mutants of Escherichia coli requiring methionine or vitamin B12. Journal of Bacteriology 60:17–28
    [Google Scholar]
  10. Dodd M. C., Stillman W. B. 1944; The in vitro bacteriostatic action of some simple furan derivatives. Journal of Pharmacology and Experimental Therapeutics 82:11–18
    [Google Scholar]
  11. Drake J. W. 1974; Mutagenesis in bacteriophage T4: direct or indirect?. In Molecular and Environmental Aspects of Mutagenesis pp. 63–72 Edited by Prakash L., Sherman F., Miller M. W., Lawrence C. W., Taber H. W. Springfield, Illinois: Charles C. Thomas;
    [Google Scholar]
  12. Endo H., Ishizawa M., Kamiya T., Kuwano M. 1963; A nitrofuran derivative, a new inducing agent for phage development in lysogenic Escherichia coli. . Biochimica et biophysica acta 68:502–505
    [Google Scholar]
  13. Fishbein L., Flamm W. G., Falk H. L. 1970 Chemical Mutagens, Environmental Effects on Biological Systems New York: Academic Press;
    [Google Scholar]
  14. Goldstein B. P., Vidal-Plana R. R., Cavalleri B., Zerilli L., Carniti G., Silvestri L. G. 1977; The mechanism of action of nitro-heterocyclic antimicrobial drugs. Metabolic activation by microorganisms. Journal of General Microbiology 100:283–298
    [Google Scholar]
  15. Ings R. M. J., Mcfadzean J. A., Ormerod W. E. 1974; The mode of action of metronidazole in Trichomonas vaginalis and other microorganisms. Biochemical Pharmacology 23:1421–1429
    [Google Scholar]
  16. Iyer V. N., Szybalski W. 1963; A molecular mechanism of mitomycin action: linking of complementary DNA strands. Proceedings of the National Academy of Sciences of the United States of America 50355–362
    [Google Scholar]
  17. Kirby E. P., Ruff W. L., Goldthwait D. A. 1972; Cell division and prophage induction in Escherichia coli: Effects of pantoyl lactone and various furan derivatives. Journal of Bacteriology 111:447–453
    [Google Scholar]
  18. Lancini G. C., Lazzari E. 1965; The synthesis of azomycin. Experientia 21:1–2
    [Google Scholar]
  19. Mahler H. R., Cordes E. H. 1966 Biological Chemistry New York: Harper & Row;
    [Google Scholar]
  20. Marmur J. 1961; A procedure for the isolation of deoxyribonucleic acid from microorganisms. Journal of Molecular Biology 3:208–218
    [Google Scholar]
  21. Mccalla D. R., Reuvers A., Kaiser C. 1970; Mode of action of nitrofurazone. Journal of Bacteriology 104:1126–1134
    [Google Scholar]
  22. Miller J. H. 1972 Experiments in Molecular Genetics Cold Spring Harbor: Cold Spring Harbor Laboratory;
    [Google Scholar]
  23. Moseley B. E. B. 1968; The repair of damaged DNA in irradiated bacteria. Advances in Microbial Physiology 2:173–194
    [Google Scholar]
  24. Paul H. E., Paul M. F. 1964; The nitrofurans-chemotherapeutic properties. Experimental Chemotherapy 2:307–370
    [Google Scholar]
  25. Ramareddy G., Reiter H. 1969; Specific loss of newly replicated deoxyribonucleic acid in nalidixic acid-treated Bacillus subtilis 168. Journal of Bacteriology 100:724–729
    [Google Scholar]
  26. Reiter H., Ramareddy G. 1970; Loss of DNA behind the growing point of thymine-starved Bacillus subtilis 168. Journal of Molecular Biology 50:533–548
    [Google Scholar]
  27. Saeki T., Umezawa H., Tokieda-Fujishige T., Hori M. 1974; Biological effects of azomycin (2-nitro- imidazole): Inhibition of ribonucleoside reductase. Journal of Antibiotics 27:225–227
    [Google Scholar]
  28. Saito H., Miura K. 1963; Preparation of transforming deoxyribonucleic acid by phenol treatment. Biochimica et biophysica acta 72:619–629
    [Google Scholar]
  29. Tu Y., Mccalla D. R. 1975; Effect of activated nitrofurans on DNA. Biochimica et biophysica acta 402:142–149
    [Google Scholar]
  30. Voogd C. E., Van Der Stel J. J., Jacobs J.J.A.A.A. 1974; The mutagenic action of nitroimidazoles. I. Metronidazole, nimorazole, dimetridazole and ronidazole. Mutation Research 26:483–490
    [Google Scholar]
  31. Voogd C. E., Van Der Stel J. J., Jacobs J.J.A.A.A. 1975; The mutagenic action of nitroimidazoles. II. Effects of 2-nitroimidazoles. Mutation Research 31:149–152
    [Google Scholar]
  32. Witkin E. M. 1974; Thermal enhancement of ultraviolet mutability in a tif-1 uvrA derivative of Escherichia coli B/r: evidence that ultraviolet mutagenesis depends upon an inducible function. Proceedings of the National Academy of Sciences of the United States of America 711930–1934
    [Google Scholar]
  33. Yahagi T., Nagao M., Kazuko H., Matsushima T., Sugimura T., Bryan G. T. 1974; Relationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives including 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, a food additive. Cancer Research 34:2266–2273
    [Google Scholar]
  34. Zampieri A., Greenberg J. 1964; Nitrofurazone as a mutagen in Escherichia coli. . Biochemical and Biophysical Research Communications 14:172–176
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-100-2-271
Loading
/content/journal/micro/10.1099/00221287-100-2-271
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error