Chromosomal Instability in Streptomyces glaucescens: Mapping of Streptomycin-sensitive Mutants
Crameri, Reto and Kieser, Tobias and Ono, Hideo and Sanchez, Jesus and Hüter, Ralf,, 129, 519-527 (1983),
doi = https://doi.org/10.1099/00221287-129-2-519,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= Streptomyces glaucescens strain GLA0 (= ETH 22794) produces hydroxystreptomycin and has a high natural resistance to hydroxystreptomycin, dihydrostreptomycin and streptomycin. The wild-type strain gives rise spontaneously to streptomycin-sensitive (StrS−) variants at a frequency of 0.2 to 1.4%. These mutants lack streptomycin phosphotransferase activity responsible for the wild-type resistance to streptomycin group antibiotics and are unable to produce detectable amounts of hydroxystreptomycin. Mapping experiments showed that the strS marker lies between the chromosomal markers lys-2 and ura-3 on the linkage map of S. glaucescens. The molecular basis for instability of this marker is as yet unknown.,
language=,
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