Mechanism of Action of Nikkomycin and the Peptide Transport System of Candida albicans
McCARTHY, PETER J. and TROKE, PETER F. and GULL, KEITH,, 131, 775-780 (1985),
doi = https://doi.org/10.1099/00221287-131-4-775,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= Nikkomycin was found to be a potent growth inhibitor of Candida albicans through competitive inhibition of chitin synthase [K i = 0·16 μm (0·1 μg ml–l)]. The activity of the peptide-nucleoside drug was antagonized by both peptone and defined peptides. Transported dipeptides were effective antagonists while transported oligopeptides were not. A mutant of C. albicans resistant to the effects of nikkomycin through a transport defect was unable to transport dipeptides, while oligopeptide uptake was apparently unaffected. At least two peptide permeases are operational in this organism.,
language=,
type=