Arginine Auxotrophs of Candida albicans Deficient in Argininosuccinate Lyase
Gibbons, Gwendolyn F. and Howard, Dexter H.,, 132, 263-268 (1986),
doi = https://doi.org/10.1099/00221287-132-2-263,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= Summary: Auxotrophic mutants of Candida albicans FC18 were induced by a combination of treatments with nitrous acid and UV irradiation. Arginine (Arg−), histidine (His−) and methionine/cysteine (MetA−) auxotrophs were recovered by this means. The Arg− auxotrophs lacked active argininosuccinate lyase (EC 4.3.2.1), the enzyme catalysing the final step in arginine biosynthesis. Thus the locus may be designated arg-4. The mutant strains bearing this mutation did not form germ tubes unless the germination medium contained arginine.,
language=,
type=