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Volume 132, Issue 6

Immunochemical Properties of the Lipopolysaccharide O-Antigen of O1 in Relation to Its Chemical Structure Free

Abstract

D-Glucuronic acid and D-glucosamine have an immunodominant role in the lipopolysaccharide (LPS) O-antigen of both the Ogawa and the Inaba subtypes of O1. This was evident from the pronounced inhibitory effect on the LPS precipitin reaction demonstrated by these monosaccharides and by oligosaccharides containing either of them which were isolated from LPS hydrolysate. There was a considerable decrease in the antibody-combining capacity of chemically modified LPS in which the carboxyl group of the glucuronic acid had been reduced. Similarly, on deamination, the O-specific polysaccharide fraction of the LPS molecule from both subtypes completely lost the ability to precipitate the LPS antibody.

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© Society for General Microbiology 1986
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1986-06-01
2024-04-25
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Immunochemical Properties of the Lipopolysaccharide O-Antigen of Vibrio cholerae O1 in Relation to Its Chemical Structure
Microbiology 132, 1641 (1986); https://doi.org/10.1099/00221287-132-6-1641
/content/journal/micro/10.1099/00221287-132-6-1641
/content/journal/micro/10.1099/00221287-132-6-1641
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