Conditionally lethal genes associated with bacterial plasmids

References

1. Akimoto S., Ohnishi Y. 1982; R483 and F plasmid genes promoting RNA degradation: comparative restriction mapping.. Microbiol Immunol 26:779–793
   [Google Scholar]
2. Austin S., Ziese M., Sternberg N. 1981; A novel role for site-specific recombination in maintenance of bacterial replicons.. Cell 25:729–736
   [Google Scholar]
3. Bahassi E.M., Salmon M.A., Van Melderen L., Bernard P., Couturier M. 1995; F plasmid CcdB killer protein: ccdB gene mutants coding for non-cytotoxic proteins which retain their regulatory functions.. Mol Microbiol 15:1031–1037
   [Google Scholar]
4. Bernard P., Couturier M. 1992; Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes.. J Mol Biol 226:735–745
   [Google Scholar]
5. Bernard P., Kezdy K.E., Van Melderen L., Steyaert J., Wyns L., Pato M.L., Higgins P.N., Couturier M. 1993; The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase.. J Mol Biol 234:534–541
   [Google Scholar]
6. Bibb M.J., Hopwood D.A. 1981; Genetic studies of the fertility plasmid SCP2 and its SCP2^* variants in Streptomyces coelicolor A3(2).. J Gen Microbiol 126:427–442
   [Google Scholar]
7. Feinstein S.I., Low K.B. 1982; Zygotic induction of the rac locus can cause cell death in E. coli.. Mol Gen Genet 187:231–235
   [Google Scholar]
8. Feng J., Yamanaka K., Niki H., Ogura T., Hiraga S. 1994; New killing system controlled by two genes located immediately upstream of the mukB gene in Escherichia coli.. Mol Gen Genet 243:136–147
   [Google Scholar]
9. Figurski D.H., Pohlman R.F., Bechhofer D.H., Prince A.S., Kelton C.A. 1982; Broad host range plasmid RK2 encodes multiple kil genes potentially lethal to Escherichia coli host cells.. Proc Natl Acad Sci USA 791935–1939
   [Google Scholar]
10. Frost L.S., Ippen-Ihler K., Skurray R.A. 1994; Analysis of the sequence and gene products of the transfer region of the F sex factor.. Microbiol Rev 58:162–210
    [Google Scholar]
11. Gerdes K., Bech F.W., Jørgensen S.T., Løbner-Olesen A., Rasmussen P.B., Atlung T., Boe L., Karlstrom O., Molin S., von Meyenburg K. 1986a; Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relBoperon.. EMBO J 5:2023–2029
    [Google Scholar]
12. Gerdes K., Rasmussen P.B., Molin S. 1986b; Unique type of plasmid maintenance function: postsegregational killing of plas-mid-free cells.. Proc Natl Acad Sci USA 833116–3120
    [Google Scholar]
13. Gerdes K., Poulsen L.K., Thisted T., Nielsen A.K., Martinussen J., Andreasen P.H. 1990a; The hok killer gene family in gramnegative bacteria.. New Biol 2:946–956
    [Google Scholar]
14. Gerdes K., Thisted T., Martinussen J. 1990b; Mechanism of post-segregational killing by the hok/sok system of plasmid R1: sok antisense RNA regulates formation of a hok mRNA species correlated with killing of plasmid-free cells.. Mol Microbiol 4:1807–1818
    [Google Scholar]
15. Goncharoff P., Saadi S., Chang C.H., Saltman L.H., Figurski D.H. 1991; Structural, molecular, and genetic analysis of the kilA operon of broad-host-range plasmid RK2.. J Bacteriol 173:3463–3477
    [Google Scholar]
16. Gottesman S., Maurizi M.R. 1992; Regulation by proteolysis: energy-dependent proteases and their targets.. Microbiol Rev 56:592–621
    [Google Scholar]
17. Grewal K.K. 1990; Plasmid RP4 host-lethal function kilA and its repressor korA sequences are part of the cryptic tellurite resistance transposon Tn521.. FEMS Microbiol Lett 57:97–99
    [Google Scholar]
18. Gross J.D. 1963; Cellular damage associated with multiple mating in Escherichia coli.. Genet Res 4:463–469
    [Google Scholar]
19. Hayes W. 1965 The Genetics of Bacteria and Their Viruses, 2nd edn.. Chichester:: John Wiley.;
    [Google Scholar]
20. Hengen P.N., Denicourt D., Iyer V.N. 1992; Isolation and characterization of kikA, a region on IncN group plasmids that determines killing of Klebsiella oxytoca.. J Bacteriol 174:3070–3077
    [Google Scholar]
21. Hiraga S. 1992; Chromosome and plasmid partition in Escherichia coli.. Annu Rev Biochem 61:283–306
    [Google Scholar]
22. Hiraga S., Jaffé A., Ogura T., Mori H., Takahashi H. 1986; F plasmid ccd mechanism in Escherichia coli.. J Bacteriol 166:100–104
    [Google Scholar]
23. Ho?�k M., Iyer V.N. 1996a; A novel plasmid gene involved in bacteriophage PRD1 infection and conjugative host-range.. Plasmid 35:204–210
    [Google Scholar]
24. Ho?�k M., Iyer V.N. 1996b; Structure and mode of action of kikA, a genetic region lethal to Klebsiella oxytoca and associated with conjugative antibiotic-resistance plasmids of the IncN group.. Plasmid 35:189–203
    [Google Scholar]
25. Hussain K., Elliott E.J., Salmond G.P. 1987; The parD^? mutant of Escherichia coli also carries a gyrA^am mutation. The complete sequence of gyrA.. Mol Microbiol 1:259–273
    [Google Scholar]
26. Jaffé A., Ogura T., Hiraga S. 1985; Effects of the ccd function of the F plasmid on bacterial growth.. J Bacteriol 163:841–849
    [Google Scholar]
27. Jensen R.B., Gerdes K. 1995; Programmed cell death in bacteria: proteic plasmid stabilization systems.. Mol Microbiol 17:205–210
    [Google Scholar]
28. Johnson E.P., Strom A.R., Helinski D.R. 1996; Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein.. J Bacteriol 178:1420–1429
    [Google Scholar]
29. Jones A.L., Barth P.T., Wilkins B.M. 1992; Zygotic induction of plasmid ssb and psiB genes following conjugative transfer of Incl1 plasmid Collb-P9.. Mol Microbiol 6:605–613
    [Google Scholar]
30. Jovanovic O.S., Ayres E.K., Figurski D.H. 1994; Host-inhibitory functions encoded by promiscuous plasmids. Transient arrest of Escherichia coli segregants that fail to inherit plasmid RK2.. J Mol Biol 237:52–64
    [Google Scholar]
31. Kataoka M., Seki T., Yoshida T. 1991; Regulation and function of the Streptomyces plasmid pSN22 genes involved in pock formation and inviability.. J Bacteriol 173:7975–7981
    [Google Scholar]
32. Kato J., Nishimura Y., Suzuki H. 1989; Escherichia coli par Ais an allele of the gyrB gene.. Mol Gen Genet 217:178–181
    [Google Scholar]
33. Kendall K.J., Cohen S.N. 1988; Complete nucleotide sequence of the Streptomyces lividans plasmid pIJ1O1 and correlation of the sequence with genetic properties.. J Bacteriol 170:4634–4651
    [Google Scholar]
34. Konisky J. 1982; Colicins and other bacteriocins with established modes of action.. Annu Rev Microbiol 36:125–144
    [Google Scholar]
35. Kornacki J.A., Chang C.H., Figurski D.H. 1993; kil-korregulon of promiscuous plasmid RK2: structure, products, and regulation of two operons that constitute the kilE locus.. J Bacteriol 175:5078–5090
    [Google Scholar]
36. Larsen M.H., Figurski D.H. 1994; Structure, expression, and regulation of the kilC operon of promiscuous IncP? plasmids.. J Bacteriol 176:5022–5032
    [Google Scholar]
37. Lehnherr H., Yarmolinsky M.B. 1995; Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli.. Proc Natl Acad Sci USA 923274–3277
    [Google Scholar]
38. Lehnherr H., Maguin E., Jafri S., Yarmolinsky M.B. 1993; Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained.. J Mol Biol 233:414–428
    [Google Scholar]
39. Loh S.M., Cram D.S., Skurray R.A. 1988; Nucleotide sequence and transcriptional analysis of a third function (Flm) involved in F-plasmid maintenance.. Gene 66:259–268
    [Google Scholar]
40. Maki S., Takiguchi S., Miki T., Horiuchi T. 1992; Modulation of DNA supercoiling activity of Escherichia coli DNA gyrase by F plasmid proteins. Antagonistic actions of LetA (CcdA) and LetD (CcdB) proteins.. J Biol Chem 267:12244–12251
    [Google Scholar]
41. Masuda Y., Miyakawa K., Nishimura Y., Ohtsubo E. 1993; chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100.. J Bacteriol 175:6850–6856
    [Google Scholar]
42. Miki T., Park J.A., Nagao K., Murayama N., Horiuchi T. 1992; Control of segregation of chromosomal DNA by sex factor F in Escherichia coli. Mutants of DNA gyrase subunit A suppress letD (ccdB) product growth inhibition.. J Mol Biol 225:39–52
    [Google Scholar]
43. Moré M.I., Pohlman R.F., Winans S.C. 1996; Genes encoding the pKM101 conjugal mating pore are negatively regulated by the plasmid-encoded KorA and KorB proteins.. J Bacteriol 178:4392–4399
    [Google Scholar]
44. Motallebi-Veshareh M., Balzer D., Lanka E., Jagura-Burdzy G., Thomas C.M. 1992; Conjugative transfer functions of broad-host-range plasmid RK2 are coregulated with vegetative replication.. Mol Microbiol 6:907–920
    [Google Scholar]
45. Naito T., Kusano K., Kobayashi I. 1995; Selfish behavior of restriction-modification systems.. Science 267:897–899
    [Google Scholar]
46. Nielsen A.K., Thorsted P., Thisted T., Wagner E.G., Gerdes K. 1991; The rifampicin-inducible genes srnB? from F and pndfrom R483 are regulated by antisense RNAs and mediate plasmid maintenance by killing of plasmid-free segregants.. Mol Microbiol 5:1961–1973
    [Google Scholar]
47. Nordstr�m K., Austin S.J. 1989; Mechanisms that contribute to the stable segregation of plasmids.. Annu Rev Genet 23:37–69
    [Google Scholar]
48. Ogura T., Hiraga S. 1983; Mini-F plasmid genes that couple host cell division to plasmid proliferation.. Proc Natl Acad Sci USA 804784–4788
    [Google Scholar]
49. Onishi Y. 1975; F factor promotes turnover of stable RNA in Escherichia coli.. Science 187:257–258
    [Google Scholar]
50. Ou J.T. 1980; Role of surface exclusion genes in lethal zygosis in Escherichia coli K12 mating.. Mol Gen Genet 178:573–581
    [Google Scholar]
51. Pecota D.C., Wood T.K. 1996; Exclusion of T4 phage by the hok/sok killer locus from plasmid R1.. J Bacteriol 178:2044–2050
    [Google Scholar]
52. Pohlman R.F., Genetti H.D., Winans S.C. 1994; Common ancestry between IncN conjugal transfer genes and macromolecular export systems of plant and animal pathogens.. Mol Microbiol 14:655–668
    [Google Scholar]
53. Poulsen L.K., Larsen N.W., Molin S., Andersson P. 1989; A family of genes encoding a cell-killing function may be conserved in all gram-negative bacteria.. Mol Microbiol 3:1463–1472
    [Google Scholar]
54. Poulsen L.K., Refn A., Molin S., Andersson P. 1991a; The gefgene from Escherichia coli is regulated at the level of translation.. Mol Microbiol 5:1639–1648
    [Google Scholar]
55. Poulsen L.K., Refn A., Molin S., Andersson P. 1991b; Topographic analysis of the toxic Gef protein from Escherichia coli.. Mol Microbiol 5:1627–1637
    [Google Scholar]
56. Poulsen L.K., Larsen N.W., Molin S., Andersson P. 1992; Analysis of an Escherichia coli mutant strain resistant to the cellkilling function encoded by the gef gene family.. Mol Microbiol 6:895–905
    [Google Scholar]
57. Roberts R.C., Spangler C., Helinski D.R. 1993; Characteristics and significance of DNA binding activity of plasmid stabilization protein ParD from the broad host-range plasmid RK2.. J Biol Chem 268:27109–27117
    [Google Scholar]
58. Roberts R.C., Strom A.R., Helinski D.R. 1994; The parDE operon of the broad-host-range plasmid RK2 specifies growth inhibition associated with plasmid loss.. J Mol Biol 237:35–51
    [Google Scholar]
59. Rodríguez M., Iyer V.N. 1981; Killing of Klebsiella pneumoniae mediated by conjugation with bacteria carrying antibiotic-resistance plasmids of the group N.. Plasmid 6:141–147
    [Google Scholar]
60. Rodríguez M., Hol?�k M., Iyer V.N. 1995; Lethality and survival of Klebsiella oxytoca evoked by conjugative IncN group plasmids.. J Bacteriol 177:6352–6361
    [Google Scholar]
61. Rotheim M.B., Love B., Gill S., Iyer V.N. 1991; Immunity: a plasmid-directed change in the Klebsiella genome.. Plasmid 25:155
    [Google Scholar]
62. Ruiz-Echevarría M.J., Berzal-Herranz A., Gerdes K., D�az-Orejas R. 1991a; The kis and kid genes of the parD maintenance system of plasmid R1 form an operon that is autoregulated at the level of transcription by the co-ordinated action of the Kis and Kid proteins.. Mol Microbiol 5:2685–2693
    [Google Scholar]
63. Ruiz-Echevarría M.J., de Torrontegui G., Gim�nez-Gallego G., D�az-Orejas R. 1991b; Structural and functional comparison between the stability systems ParD of plasmid R1 and Ccd of plasmid F.. Mol Gen Genet 225:355–362
    [Google Scholar]
64. Ruiz-Echevarría M.J., de la Cueva G., D�az-Orejas R. 1995a; Translational coupling and limited degradation of a polycistronic messenger modulate differential gene expression in the parDstability system of plasmid R1.. Mol Gen Genet 248:599–609
    [Google Scholar]
65. Ruiz-Echevarría M.J., Gim�nez-Gallego G., Sabariegos-Jareno R., D�az-Orejas R. 1995b; Kid, a small protein of the parDstability system of plasmid R1, is an inhibitor of DNA replication acting at the initiation of DNA synthesis.. J Mol Biol 247:568–577
    [Google Scholar]
66. Salmon M.A., Van Melderen L., Bernard P., Couturier M. 1994; The antidote and autoregulatory functions of the F plasmid CcdA protein: a genetic and biochemical survey.. Mol Gen Genet 244:530–538
    [Google Scholar]
67. Saltman L.H., Kim K.S., Figurski D.H. 1991; The kilA operon of promiscuous plasmid RK2: the use of a transducing phage (? pklaA-1) to determine the effects of the lethal klaA gene on Escherichia coli cells.. Mol Microbiol 5:2673–2683
    [Google Scholar]
68. Schreiner H.C., Bechhofer D.H., Pohlman R.F., Young C., Borden P.A., Figurski D.H. 1985; Replication control in promiscuous plasmid RK2: kil and kor functions affect expression of the essential replication gene trfA.. J Bacteriol 163:228–237
    [Google Scholar]
69. Sia E.A., Roberts R.C., Easter C., Helinski D.R., Figurski D.H. 1995; Different relative importances of the par operons and the effect of conjugal transfer on the maintenance of intact promiscuous plasmid RK2.. J Bacteriol 177:2789–2797
    [Google Scholar]
70. Skurray R.A., Reeves P. 1973; Physiology of Escherichia coliK-12 during conjugation: altered recipient cell functions associated with lethal zygosis.. J Bacteriol 114:11–17
    [Google Scholar]
71. Sonea S. 1991; Bacterial evolution without speciation.. In Symbiosis as a Source of Evolutionary Innovation pp. 145–155 Margulis L., Fester R. Edited by Cambridge, MA & London:: MIT Press.;
    [Google Scholar]
72. Stein D.S., Kendall K.J., Cohen S.N. 1989; Identification and analysis of transcriptional regulatory signals for the kil and korloci of Streptomyces plasmid pIJ1O1.. J Bacteriol 171:5768–5775
    [Google Scholar]
73. Summers D.K., Sherratt D.J. 1984; Multimerization of high copy number plasmids causes instability: CoIEl encodes a determinant essential for plasmid monomerization and stability.. Cell 36:1097–1103
    [Google Scholar]
74. Tai J.T., Cohen S.N. 1993; The active form of the KorB protein encoded by the Streptomyces plasmid pi J101 is a processed product that binds differentially to the two promoters it regulates.. J Bacteriol 175:6996–7005
    [Google Scholar]
75. Tai J.T., Cohen S.N. 1994; Mutations that affect regulation of the korB gene of Streptomyces lividans plasmid plJ101 alter plasmid transmission.. Mol Microbiol 12:31–39
    [Google Scholar]
76. Tam J.E., Kline B.C. 1989a; Control of the ccd operon in plasmid F.. J Bacteriol 171:2353–2360
    [Google Scholar]
77. Tam J.E., Kline B.C. 1989b; The F plasmid ccd autorepressor is a complex of CcdA and CcdB proteins.. Mol Gen Genet 219:26–32
    [Google Scholar]
78. Thatte V., Gill S., Iyer V.N. 1985; Regions on plasmid pCU1 required for the killing of Klebsiella pneumoniae.. J Bacteriol 163:1296–1299
    [Google Scholar]
79. Thisted T., Gerdes K. 1992; Mechanism of post-segregational killing by the hok/sok system of plasmid R1. Sok antisense RNA regulates hok gene expression indirectly through the overlapping mok gene.. J Mol Biol 223:41–54
    [Google Scholar]
80. Thisted T., Nielsen A.K., Gerdes K. 1994a; Mechanism of post-segregational killing: translation of Hok, SrnB and Pnd mRNAs of plasmids R1, F and R483 is activated by 3?-end processing.. EMBO J 13:1950–1959
    [Google Scholar]
81. Thisted T., Sorensen N.S., Wagner E.G., Gerdes K. 1994b; Mechanism of post-segregational killing: Sok antisense RNA interacts with Hok mRNA via its 5?-end single-stranded leader and competes with the 3?-end of Hok mRNA for binding to the mok translational initiation region.. EMBO J 13:1960–1968
    [Google Scholar]
82. Thisted T., Sorensen N.S., Gerdes K. 1995; Mechanism of post-segregational killing: secondary structure analysis of the entire Hok mRNA from plasmid R1 suggests a fold-back structure that prevents translation and antisense RNA binding.. J Mol Biol 247:859–873
    [Google Scholar]
83. Thomas C.M., Smith C.A., Ibbotson J.P., Johnston L., Wang N. 1995; Evolution of the korA-oriV segment of promiscuous IncP plasmids.. Microbiology 141:1201–1210
    [Google Scholar]
84. Thomson V.J., Jovanovic O.S., Pohlman R.F., Chang C.H., Figurski D.H. 1993; Structure, function, and regulation of the kilB locus of promiscuous plasmid RK2.. J Bacteriol 175:2423–2435
    [Google Scholar]
85. Tian Q.B., Ohnishi M., Tabuchi A., Terawaki Y. 1996; A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rtsl.. Biochem Biophys Res Commun 220:280–284
    [Google Scholar]
86. Tsuchimoto S., Ohtsubo H., Ohtsubo E. 1988; Two genes, pemK and pemI, responsible for stable maintenance of resistance plasmid R100.. J Bacteriol 170:1461–1466
    [Google Scholar]
87. Tsuchimoto S., Nishimura Y., Ohtsubo E. 1992; The stable maintenance system pem of plasmid R100: degradation of PemI protein may allow PemK protein to inhibit cell growth.. J Bacteriol 174:4205–4211
    [Google Scholar]
88. Van Melderen L., Bernard P., Couturier M. 1994; Lon-dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid-free segregant bacteria.. Mol Microbiol 11:1151–1157
    [Google Scholar]
89. Williams D.R., Thomas C.M. 1992; Active partitioning of bacterial plasmids.. J Gen Microbiol 138:1–16
    [Google Scholar]
90. Winans S.C., Walker G.C. 1985; Identification of pKM101-encoded loci specifying potentially lethal gene products.. J Bacteriol 161:417–424
    [Google Scholar]
91. Young C., Prince A.S., Figurski D.H. 1985; korA function of promiscuous plasmid Rk2: an autorepressor that inhibits expression of host-lethal gene kilA and replication gene trfA.. Proc Natl Acad Sci USA 827374–7378
    [Google Scholar]
92. Zaman S., Richards H., Ward J. 1992; Expression and characterisation of the korB gene product from the Streptomyces lividans plasmid pIJ101 in Escherichia coli and determination of its binding site on the korB and kilB promoters.. Nucleic Acids Res 20:3693–3700
    [Google Scholar]