Use of a glycerol-limited, long-term chemostat for isolation of Escherichia coli mutants with improved physiological properties

References

1. Bachmann B. J. 1987; Derivations and genotypes of some mutant derivatives of Escherichia coli K-12. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, Edited by F. C. Neidhardt, J. L. Ingraham, K. Brooks Low, B. Magasanik, M. Schaechter & H. E. Umbarger. Washington, DC:. American Society for Microbiology1190–1219.
   [Google Scholar]
2. Calhoun M. W., Oden K. L., Gennis R. B., Teixeira de Mattos M. J., Neijssel O. M. 1993; Energetic efficiency of Escherichia coli: effects of mutations in components of the aerobic respiratory chain. J Bacteriol 175:3020–3025.
   [Google Scholar]
3. Cheng C. Y., Yabe I., Toda K. 1989; Predominant growth of alpha-amylase regulation mutant in continuous culture of Bacillus caldolyticus. J Ferment Bioeng 67:176–181.
   [Google Scholar]
4. Chesbro W., Arbige M., Eifert R. 1990; When nutrient limitation places bacteria in the domains of slow growth: metabolic, morphologic and cell cycle behavior. FEMS Microbiol Ecol 74:103–119.
   [Google Scholar]
5. Chou C.-H., Bennett G. N., San K.-Y. 1994; Effect of modified glucose uptake using genetic engineering techniques on high-level recombinant protein production in Escherichia coli dense cultures. Biotechnol Bioeng 44:952–960.
   [Google Scholar]
6. Contois D. E. 1959; Kinetics of bacterial growth: relationship between population density and specific growth rate in continuous cultures. J Gen Microbiol 21:40–50.
   [Google Scholar]
7. Dedhia N. N., Hottinger T., Bailey J. E. 1994; Overproduction of glycogen in Escherichia coli blocked in the acetate pathway improves cell-growth. Biotechnol Bioeng 44:132–139.
   [Google Scholar]
8. Dykhuizen D., Hartl D. 1981; Evolution of competitive ability in Escherichia coli. Evolution 35:581–594.
   [Google Scholar]
9. Dykhuizen D. E., Hartl D. L. 1983; Selection in chemostats. Microbiol Rev 47:150–168.
   [Google Scholar]
10. Helling R. B., Vargas C. N., Adams J. 1987; Evolution of Escherichia coli during growth in a constant environment. Genetics 116:349–358.
    [Google Scholar]
11. Kakuda H., Shiroishi K., Hosono K., Ichihara S. 1994; Construction of a Pta-Ack pathway deletion mutant of Escherichia coli and characteristic growth profiles of the mutants in a rich medium. Biosci Biotechnol Biochem 58:2232–2235.
    [Google Scholar]
12. Kubitschek H. E. 1970; Zntroduction to Research with Continuous Cultures. Englewood-Cliffs:. Prentice-Hall.
    [Google Scholar]
13. Kurland C. G. 1992; Translational accuracy and the fitness of bacteria. Annu Rev Genet 26:29–50
    [Google Scholar]
14. MacPhee D. G. 1993; Directed mutations: a critical analysis. ASM News 59:297–299
    [Google Scholar]
15. Matin A. 1992; Physiology, molecular biology and applications of the bacterial starvation response. J Appl Bacteriol Symp (Suppl.) 73:49S–57S
    [Google Scholar]
16. Matin A., Auger E. A., Blum P. H., Schultz J. E. 1989; Genetic basis of starvation survival in nondifferentiating bacteria. Annu Rev Microbiof 43:293–316
    [Google Scholar]
17. Moser H. 1958; The Dynamics of Bacterial Populations Maintained in the Chemostat. Washington, DC:. Carnegie Institute of Washington (Publication 61).
    [Google Scholar]
18. Notley L., Ferenci T. 1996; Induction of RhoS-dependent functions in glucose-limited continuous culture: what level of nutrient limitation induces the stationary phase of Escherichia coli. J Bacteriol 178:1465–1468
    [Google Scholar]
19. Novick A., Szilard L. 1950; Experiments with the chemostat on spontaneous mutations in bacteria. Proc Natl Acad Sci USA 36:708–719
    [Google Scholar]
20. Paquin C ., Adams J. 1983; Frequency of fixation of adaptive mutations is higher in evolving diploid than haploid yeast populations. Nature 302:495–500
    [Google Scholar]
21. Rosenzweig R. F., Sharp R. R., Treves D. S., Adams J. 1994; Microbial evolution in a simple unstructured environment: genetic differentiation in Escherichia coli. Genetics 137:1–13
    [Google Scholar]
22. Sakamoto S., Terada I., Lee Y. C., Uehara K., Matsuzawa H., Ijima M. 1996; Efficient production of Thermus protease aqualysin-1 in Escherichia coli: effect of cloned gene structure and 2-stage culture. Appl Microbiol Biotechnol 45:94–101
    [Google Scholar]
23. Svitil A. L., Cashel M., Zyskind J. W. 1993; Guanosine tetraphosphate inhibits protein synthesis in vivo. J Biol Chem 268:2307–2311
    [Google Scholar]
24. Tedin K., Bremer H. 1992; Toxic effects of high levels of ppGpp in Escherichia coli are relieved by rpoB mutations. J Biol Chem 267:2337–2344
    [Google Scholar]
25. Williams S. G., Greenwood J. A., Jones C. W. 1994; The effect of nutrient limitation on glycerol uptake and metabolism in continuous cultures of Pseudomonas aeruginosa. Microbiology 140:2961–2969
    [Google Scholar]