The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis
Brunskill, Eric W. and de Jonge, Boudewijn L. M. and Bayles, Kenneth W.,, 143, 2877-2882 (1997),
doi = https://doi.org/10.1099/00221287-143-9-2877,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= Summary: A new Staphylococcus aureus gene termed scdA was found upstream of the autolysis regulatory genes, lytS and lytR, and was shown to potentially encode a hydrophilic 25 kDa protein. Analysis of scdA transcription revealed that it is transcribed as a monocistronic message and is lytSR-independent. A role in cell wall metabolism was indicated by examination of the scdA mutant S. aureus KB323, which had a grossly aberrant cellular morphology and formed large cell clusters when grown in liquid culture medium. Furthermore, KB323 exhibited a reduced rate of autolysis and had increased peptidoglycan cross-linking compared to the parental strain, NCTC 8325-4. These data suggest that scdA plays an important role in staphylococcal cell division.,
language=,
type=