RT Journal Article SR Electronic(1) A1 Brunskill, Eric W. A1 de Jonge, Boudewijn L. M. A1 Bayles, Kenneth W.YR 1997 T1 The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis JF Microbiology, VO 143 IS 9 SP 2877 OP 2882 DO https://doi.org/10.1099/00221287-143-9-2877 PB Microbiology Society, SN 1465-2080, AB Summary: A new Staphylococcus aureus gene termed scdA was found upstream of the autolysis regulatory genes, lytS and lytR, and was shown to potentially encode a hydrophilic 25 kDa protein. Analysis of scdA transcription revealed that it is transcribed as a monocistronic message and is lytSR-independent. A role in cell wall metabolism was indicated by examination of the scdA mutant S. aureus KB323, which had a grossly aberrant cellular morphology and formed large cell clusters when grown in liquid culture medium. Furthermore, KB323 exhibited a reduced rate of autolysis and had increased peptidoglycan cross-linking compared to the parental strain, NCTC 8325-4. These data suggest that scdA plays an important role in staphylococcal cell division., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-143-9-2877