Oocydin A, a chlorinated macrocyclic lactone with potent anti- oomycete activity from Serratia marcescens
Strobel, Gary and Li, Jia-Yao and Sugawara, Fumio and Koshino, Hiroyuki and Harper, James and Hess, W. M.,, 145, 3557-3564 (1999),
doi = https://doi.org/10.1099/00221287-145-12-3557,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= A unique chlorinated macrocyclic lactone, termed oocydin A, was isolated from a strain of Serratia marcescens growing as an epiphyte on Rhyncholacis pedicillata, an aquatic plant native to the Carrao river of the Venezuelan-Guyanan region of South America. The lactone has a molecular mass of 470 Da, and contains one atom of chlorine, a carboxyl group and a tetrahydrofuran ring internal to a larger macrocyclic ring. MICs of approximately 0·03 μg ml−1 were noted for oocydin A against such phytopathogenic oomycetes as Pythium ultimum, Phytophthora parasitica, Phytophthora cinnamomi and Phytophthora citrophora. With regard to the true fungi, oocydin A had either minimal or no effect against certain Fungi Imperfecti (including several pathogens of humans), two ascomycetes and a basidiomycete. Oocydin A may have potential as an antimycotic in agricultural applications and especially for crop protection.,
language=,
type=