1887

Abstract

SUMMARY: The fungi and were cultivated (i) in malt extract solutions with various concentrations of rubratoxin B (100, 10, 1 μg/ml) in order to study the hyphal morphology and (ii) on filter discs containing different amounts of the same toxin (100, 10, 1 μg/disc) to detect any influence on sporulation. In the presence of 100 μg toxin/ml the hyphal tips of and were very often swollen and much septate, or were transformed into giant cells. Plasmoptysis often occurred. The germ tubes of were much deformed. It is assumed that all these toxic effects were caused by weakening of the hyphal tips by interference with wall synthesis. Rubratoxin B (100 μg/disc) completely inhibited the sporulation of all of the fungi. Lower concentrations diminished sporulation of most of the fungi.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-71-1-167
1972-06-01
2024-04-27
Loading full text...

Full text loading...

/deliver/fulltext/micro/71/1/mic-71-1-167.html?itemId=/content/journal/micro/10.1099/00221287-71-1-167&mimeType=html&fmt=ahah

References

  1. DARGENT R. 1969; Nouvelles observations sur le phénomène de plasmoptysie.. Comptes rendus de l’ Académie des sciences, Serie D269:882–885
    [Google Scholar]
  2. Edwards G. S., Wogan G. N. 1968; Acute and chronic toxicity of rubratoxin in rats.. Federation Proceedings 27:552
    [Google Scholar]
  3. HAYES A. W., WILSON B. J. 1968; Bioproduction and purification of rubratoxin B.. Applied Microbiology 16:1163–1167
    [Google Scholar]
  4. HAYES A. W., WYATT E. P. 1970; Survey of the sensitivity of microorganisms to rubratoxin B.. Applied Microbiology 20:164–165
    [Google Scholar]
  5. LILLEHOJ E. B., CIEGLER A., HALL H. H. 1967; Fungistatic action of aflatoxin B1 Experientia. 23:187
    [Google Scholar]
  6. MOREAU C., MOREAU M. 1968; Recherche des metabolites toxiques du Phialophora cinerescens (Wr.) v. Beyma: altérations des tubes germinatifs chez le Fusarium roseum (Lk.) Sn. et H. (culmorum).. Bulletin de la Societé botanique de France 115:42–47
    [Google Scholar]
  7. Moss M. O., ROBINSON F. V., WOOD A. B. 1967; Observations on the structure of the toxins from PeniciUium rubrum.. Chemistry and Industry 1967:755–757
    [Google Scholar]
  8. Moss M. O., ROBINSON F. V., WOOD A. B. 1968; Rubratoxin B, a toxic metabolite of PeniciUium rubrum.. Chemistry and Industry 1968:587–588
    [Google Scholar]
  9. Moss M. O., ROBINSON F. V., WOOD A. B., PAISLEY H. M., FEENEY J. 1968 Rubratoxin B, a proposed structure for a bis-anhydride from PeniciUium rubrum Stoll.. Nature, London 220767–770
    [Google Scholar]
  10. Moss M. O., WOOD A. B., ROBINSON F. V. 1969; The structure of rubratoxin A, a toxic metabolite of Penicillium rubrum.. Tetrahedron Letters no. 5:367–370
    [Google Scholar]
  11. NATORI S., SASAKI S., KURATA H., UDAGAWA S., ICHINOE M., SAITO M., UMEDA M., OHTSUBO K. 1970; Production of rubratoxin B by Penicilliumpurpurogenum Stoll.. Applied Microbiology 19:613–617
    [Google Scholar]
  12. ONG T. 1970; Mutagenicity of aflatoxins in Neurospora crassa.. Mutation Research 9:615–618
    [Google Scholar]
  13. REISS J. 1970a; Untersuchungen iiber den Einfluss von Aflatoxin B1 auf die Morphologie und die cyto-chemisch fassbare Aktivit#x00E4;t einiger Enzyme von Mucor hiemalis (Mucorales).. Mycopathologia et mycologia applicata 42:225–231
    [Google Scholar]
  14. REISS J. 1970b; A simple cultivation chamber for the study of aerial reproductive elements of fungi.. Journal of General and Applied Microbiology 16:185–187
    [Google Scholar]
  15. REISS J. 1971a; Inhibition of fungal sporulation by aflatoxin.. Archiv f#x00F6;r Mikrobiologie 76:219–222
    [Google Scholar]
  16. REISS J. 1971b; Hyphenanomalien bei Thamnidium elegans Link durch Aflatoxin B1. Zeitschrift ftir allgemeine Mikrobiologie 11:637–638
    [Google Scholar]
  17. REISS J. 1971c; Hemmung der Keimung der Kresse (Lepidium sativum) durch Aflatoxin B1 und Rubratoxin B.. Biochemie und Physiologie der Pflanzen 162:363–367
    [Google Scholar]
  18. Rizvi S.R.H., ROBERTSON N. F. 1965; Apical disintegration of hyphae of Neurospora crassa as a response to L-sorbose.. Transactions of the British Mycological Society 48:469–477
    [Google Scholar]
  19. ROBERTSON N. F., RIZVI S. R. H. 1968; Some observations on the water-relations of the hypnae of Neurospora crassa.. Annals of Botany 32:279–291
    [Google Scholar]
  20. Talburt D. E., JOHNSON G. T. 1955; Plasmoptysis of filamentous fungi.. Mycologia 57:660–662
    [Google Scholar]
  21. TOWNSEND R. J., Moss M. O., PECK H. M. 1966; Isolation and characterization of hepatotoxins from Penicillium rubrum.. Journal of Pharmacy and Pharmacology 18:471–473
    [Google Scholar]
  22. WILDMAN J. D. 1966; Note on occurrence of giant cells in Aspergillus flavus Link.. Journal of the Association of Official Analytical Chemists 49:562–566
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-71-1-167
Loading
/content/journal/micro/10.1099/00221287-71-1-167
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error