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f Systems and synthetic biology perspective of the versatile plant-pathogenic and polysaccharide-producing bacterium Xanthomonas campestris
- Authors: Sarah Schatschneider1,‡ , Jessica Schneider2,‡ , Jochen Blom3 , Fabien Létisse4 , Karsten Niehaus1 , Alexander Goesmann3,† , Frank-Jörg Vorhölter5,§,†
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- VIEW AFFILIATIONS
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1 1Abteilung für Proteom und Metabolomforschung, Centrum für Biotechnologie (CeBiTec), Universität Bielefeld, Bielefeld, Germany 2 2Bioinformatics Resource Facility, Centrum für Biotechnologie, Universität Bielefeld, Germany 3 3Bioinformatics and Systems Biology, Justus-Liebig-University Gießen, Germany 4 4LISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse, France 5 5Institut für Genomforschung und Systembiologie, Centrum für Biotechnology (CeBiTec), Universität Bielefeld, Bielefeld, Germany ‡ ‡Present address: Evonik Nutrition and Care GmbH, Kantstr. 2, 33790 Halle-Künsebeck, Germany. § §Present address: MVZ Dr. Eberhard & Partner Dortmund, Dortmund, Germany.
- *Correspondence: Sarah Schatschneider, [email protected]
- First Published Online: 10 August 2017, Microbiology 163: 1117-1144, doi: 10.1099/mic.0.000473
- Subject: Review
- Received:
- Accepted:
- Cover date:




Systems and synthetic biology perspective of the versatile plant-pathogenic and polysaccharide-producing bacterium Xanthomonas campestris, Page 1 of 1
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Bacteria of the genus Xanthomonas are a major group of plant pathogens. They are hazardous to important crops and closely related to human pathogens. Being collectively a major focus of molecular phytopathology, an increasing number of diverse and intricate mechanisms are emerging by which they communicate, interfere with host signalling and keep competition at bay. Interestingly, they are also biotechnologically relevant polysaccharide producers. Systems biotechnology techniques have revealed their central metabolism and a growing number of remarkable features. Traditional analyses of Xanthomonas metabolism missed the Embden–Meyerhof–Parnas pathway (glycolysis) as being a route by which energy and molecular building blocks are derived from glucose. As a consequence of the emerging full picture of their metabolism process, xanthomonads were discovered to have three alternative catabolic pathways and they use an unusual and reversible phosphofructokinase as a key enzyme. In this review, we summarize the synthetic and systems biology methods and the bioinformatics tools applied to reconstruct their metabolic network and reveal the dynamic fluxes within their complex carbohydrate metabolism. This is based on insights from omics disciplines; in particular, genomics, transcriptomics, proteomics and metabolomics. Analysis of high-throughput omics data facilitates the reconstruction of organism-specific large- and genome-scale metabolic networks. Reconstructed metabolic networks are fundamental to the formulation of metabolic models that facilitate the simulation of actual metabolic activities under specific environmental conditions.
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†
These authors contributed equally to this work.
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Dedicated to Alf Pühler who initiated much of the systems biology research related to Xanthomonas campestris.
- Keyword(s): infection, metabolic modelling, OMICS, biotechnology, bioinformatics tools, plant pathogenesis
© 2017 The Authors
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