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oa Microbe Profile: Corynebacterium diphtheriae – an old foe always ready to seize opportunity
- By Paul A. Hoskisson1
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- VIEW AFFILIATIONS
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1 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK
- *Correspondence: Paul A. Hoskisson [email protected]
- First Published Online: 21 February 2018, Microbiology 164: 865-867, doi: 10.1099/mic.0.000627
- Subject: Microbe Profile
- Received:
- Accepted:
- Cover date:
- This is an open access article published by the Microbiology Society under the Creative Commons Attribution License




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Corynebacterium diphtheriae is a globally important Gram-positive aerobic Actinobacterium capable of causing the toxin-mediated disease, diphtheria. Diphtheria was a major cause of childhood mortality prior to the introduction of the toxoid vaccine, yet it is capable of rapid resurgence following the breakdown of healthcare provision, vaccination or displacement of people. The mechanism and treatment of toxin-mediated disease is well understood, however there are key gaps in our knowledge on the basic biology of C. diphtheriae particularly relating to host colonisation, the nature of asymptomatic carriage, population genomics and host adaptation.
- Keyword(s): actinobacteria, Corynebacterium diphtheriae, exotoxin, diphtheria, toxin
© 2018 The Authors
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