%0 Journal Article %A Stoeva, Magdalena K. %A Coates, John D. %T Specific inhibitors of respiratory sulfate reduction: towards a mechanistic understanding %D 2019 %J Microbiology, %V 165 %N 3 %P 254-269 %@ 1465-2080 %R https://doi.org/10.1099/mic.0.000750 %K sulfate transport %K sulfate reduction %K specific inhibition %K sulfate adenylyltransferase %K monovalent and divalent oxyanions %I Microbiology Society, %X Microbial sulfate reduction (SR) by sulfate-reducing micro-organisms (SRM) is a primary environmental mechanism of anaerobic organic matter mineralization, and as such influences carbon and sulfur cycling in many natural and engineered environments. In industrial systems, SR results in the generation of hydrogen sulfide, a toxic, corrosive gas with adverse human health effects and significant economic and environmental consequences. Therefore, there has been considerable interest in developing strategies for mitigating hydrogen sulfide production, and several specific inhibitors of SRM have been identified and characterized. Specific inhibitors are compounds that disrupt the metabolism of one group of organisms, with little or no effect on the rest of the community. Putative specific inhibitors of SRM have been used to control sulfidogenesis in industrial and engineered systems. Despite the value of these inhibitors, mechanistic and quantitative studies into the molecular mechanisms of their inhibition have been sparse and unsystematic. The insight garnered by such studies is essential if we are to have a more complete understanding of SR, including the past and current selective pressures acting upon it. Furthermore, the ability to reliably control sulfidogenesis – and potentially assimilatory sulfate pathways – relies on a thorough molecular understanding of inhibition. The scope of this review is to summarize the current state of the field: how we measure and understand inhibition, the targets of specific SR inhibitors and how SRM acclimatize and/or adapt to these stressors. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000750