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Volume 165, Issue 5

The relevance of persisters in tuberculosis drug discovery Open Access

Abstract

Bacterial persisters are a subpopulation of cells that exhibit phenotypic resistance during exposure to a lethal dose of antibiotics. They are difficult to target and thought to contribute to the long treatment duration required for tuberculosis. Understanding the molecular and cellular biology of persisters is critical to finding new tuberculosis drugs that shorten treatment. This review focuses on mycobacterial persisters and describes the challenges they pose in tuberculosis therapy, their characteristics and formation, how persistence leads to resistance, and the current approaches being used to target persisters within mycobacterial drug discovery.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antibiotics , drug discovery , mycobacteria , non-replicating organisms , persistence and tuberculosis
© 2019 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2019-05-01
2024-04-26
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The relevance of persisters in tuberculosis drug discovery
Microbiology 165, 492 (2019); https://doi.org/10.1099/mic.0.000760
/content/journal/micro/10.1099/mic.0.000760
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