RT Journal Article SR Electronic(1) A1 Dunn, M. F. A1 Ramírez-Trujillo, J. A. A1 Hernández-Lucas, I.YR 2009 T1 Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis JF Microbiology, VO 155 IS 10 SP 3166 OP 3175 DO https://doi.org/10.1099/mic.0.030858-0 PB Microbiology Society, SN 1465-2080, AB The glyoxylate cycle is an anaplerotic pathway of the tricarboxylic acid (TCA) cycle that allows growth on C2 compounds by bypassing the CO2-generating steps of the TCA cycle. The unique enzymes of this route are isocitrate lyase (ICL) and malate synthase (MS). ICL cleaves isocitrate to glyoxylate and succinate, and MS converts glyoxylate and acetyl-CoA to malate. The end products of the bypass can be used for gluconeogenesis and other biosynthetic processes. The glyoxylate cycle occurs in Eukarya, Bacteria and Archaea. Recent studies of ICL- and MS-deficient strains as well as proteomic and transcriptional analyses show that these enzymes are often important in human, animal and plant pathogenesis. These studies have extended our understanding of the metabolic pathways essential for the survival of pathogens inside the host and provide a more complete picture of the physiology of pathogenic micro-organisms. Hopefully, the recent knowledge generated about the role of the glyoxylate cycle in virulence can be used for the development of new vaccines, or specific inhibitors to combat bacterial and fungal diseases., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.030858-0