RT Journal Article SR Electronic(1) A1 Petříčková, Kateřina A1 Petříček, MiroslavYR 2003 T1 Eukaryotic-type protein kinases in Streptomyces coelicolor: variations on a common theme JF Microbiology, VO 149 IS 7 SP 1609 OP 1621 DO https://doi.org/10.1099/mic.0.26275-0 PB Microbiology Society, SN 1465-2080, AB The increasing number of genes encoding eukaryotic-type Ser/Thr protein kinases (ESTPKs) in prokaryotes, identified mostly due to genome-sequencing projects, suggests that these enzymes play an indispensable role in many bacterial species. Some prokaryotes, such as Streptomyces coelicolor, carry numerous genes of this type. Though the regulatory pathways have been intensively studied in the organism, experimental proof of the physiological function of ESTPKs is scarce. This review presents a family portrait of the genes identified in the sequence of the S. coelicolor A3(2) genome. Based on the available experimental data on ESTPKs in streptomycetes and related bacteria, and on computer-assisted sequence analyses, possible roles of these enzymes in the regulation of cellular processes in streptomycetes are suggested., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.26275-0