Virulence attenuation in Salmonella enterica rcsC mutants with constitutive activation of the Rcs system
García-Calderón, Clara B. and García-Quintanilla, Meritxell and Casadesús, Josep and Ramos-Morales, Francisco,, 151, 579-588 (2005),
doi = https://doi.org/10.1099/mic.0.27520-0,
publicationName = Microbiology Society,
issn = 1350-0872,
abstract= Mutations in rcsC that result in constitutive colanic acid capsule synthesis were obtained in Salmonella enterica serovar Typhimurium. Most rcsC alleles were dominant; however, recessive rcsC alleles were also found, in agreement with the postulated double role (positive and negative) of RcsC on the activation of the RcsB/C phosphorelay system. Salmonella rcsC mutants with constitutive activation of the Rcs system are severely attenuated for virulence in BALB/c mice and their degree of attenuation correlates with the level of Rcs activation. Partial relief of attenuation by a gmm mutation indicates that capsule overproduction is one of the factors leading to avirulence in constitutively activated rcsC mutants.,
language=,
type=