1887

Abstract

Genetic and reversion analyses of a thermosensitive pleiotropic mutant strain of with defects in nitrogen fixation and nitrogen metabolism have shown that the pleiotropic behaviour of the mutant is due to a single mutation in a gene designated . This gene is cotransducible with at a frequency of about 30% (using bacteriophage P1) and with at a frequency of about 14%. The gene order is . The defect in the mutant is complemented by the F′ element, F′148.

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/content/journal/micro/10.1099/00221287-116-2-501
1980-02-01
2024-05-06
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References

  1. Arst H. N. Jr Cove D. J. 1973; Nitrogen metabolite repression in Aspergillus nidulans. Molecular and General Genetics 126:111–141
    [Google Scholar]
  2. Brenchley J. E., Prival M. J., Magasanik B. 1973; Regulation of the synthesis of enzymes responsible for glutamate formation in Klebsiella aerogenes. Journal of Biological Chemistry 248:6122–6128
    [Google Scholar]
  3. Broach J., Neumann C., Kustu S. 1976; Mutant strains (nit) of Salmonella typhimuriumwith a pleiotropic defect in nitrogen metabolism. Journal of Bacteriology 128:86–98
    [Google Scholar]
  4. Janssen K., Magasanik B. 1977; Glutamine synthetase of Klebsiella aerogenes: genetic and physiological properties of mutants in the adenylylation system. Journal of Bacteriology 129:993–1000
    [Google Scholar]
  5. Low K. B. 1972; Escherichia coli K-12 F-prime factors, old and new. Bacteriological Reviews 36:587–607
    [Google Scholar]
  6. Magasanik B. 1976; Classical and postclassical modes of regulation of the synthesis of degradative bacterial enzymes. Progress in Nucleic Acid Research and Molecular Biology 17:99–115
    [Google Scholar]
  7. Magasanik B., Prival M. J., Brenchley M. E., Tyler B. M., Deleo A. B., Streicher S. L., Bender R. A., Paris C. G. 1974; Glutamine synthetase as a regulator of enzyme synthesis. Current Topics in Cellular Regulation 8:119–138
    [Google Scholar]
  8. Miller J. H. 1972 Experiments in Molecular Genetics New York:: Cold Spring Harbor Laboratory;
    [Google Scholar]
  9. Murgola E. J., Yanofsky C. 1974; Structural interactions between amino acid residues at positions 22 and 211 in tryptophan synthetase alpha chain of Escherichia coli. Journal of Bacteriology 117:444–448
    [Google Scholar]
  10. Nagatani H., Shimizu M., Valentine R. C. 1971; The mechanism of ammonia assimilation in nitrogen-fixing bacteria. Archiv für Mikrobiologie 19:164–175
    [Google Scholar]
  11. Parejko R. A., Wilson P. W. 1971; Regulation of nitrogenase synthesis by Klebsiella pneumoniae. Canadian Journal of Microbiology 16:681–685
    [Google Scholar]
  12. Postgate J. R. 1970 The Chemistry and Biochemistry of Nitrogen Fixation London:: Plenum Press;
    [Google Scholar]
  13. Sanderson K. E., Hartman P. E. 1978; Linkage map of Salmonella typhimurium, edition V. Microbiological Reviews 42:471–519
    [Google Scholar]
  14. Shanmugam K. T., Morandi C. 1976; Amino-acids as repressors of nitrogenase biosynthesis in Klebsiella pneumoniae. Biochimica et biophysica acta 437:322–332
    [Google Scholar]
  15. Shanmugam K. T., Valentine R. C. 1975; Molecular biology of nitrogen fixation. Science 187:919–924
    [Google Scholar]
  16. Shanmugam K. T., Valentine R. C. 1979; Nitrogen fixation (Nif) mutants of Klebsiella pneumoniae. Methods in Enzymology (in the Press)
    [Google Scholar]
  17. Shanmugam K. T., Loo A. S., Valentine R. C. 1974; Deletion mutants of nitrogen fixation in Klebsiella pneumoniae: mapping of a cluster of nif genes essential for nitrogenase activity. Biochimica et biophysica acta 338:545–554
    [Google Scholar]
  18. Shanmugam K. T., O’gara F., Andersen K., Valentine R. C. 1978; Biological nitrogen fixation. Annual Review of Plant Physiology 29:263–276
    [Google Scholar]
  19. Strauss B. S. 1962; Response of Escherichia coliauxotrophs to heat after treatment with mutagenic alkyl methane sulfonates. Journal of Bacteriology 83:241–249
    [Google Scholar]
  20. Streicher S., Gurney E., Valentine R. C. 1971; Transduction of the nitrogen-fixation genes in Klebsiella pneumoniae. Proceedings of the National Academy of Sciences of the United States of America 68:1174–1177
    [Google Scholar]
  21. Tubb R. S. 1974; Glutamine synthetase and ammonium regulation of nitrogenase synthesis in Klebsiella. Nature; London: 251481–485
    [Google Scholar]
  22. Tyler B. 1978; Regulation of the assimilation of nitrogen compounds. Annual Review of Biochemistry 47:1127–1162
    [Google Scholar]
  23. Tyler B. A., Deleo A. B., Magasanik B. 1974; Activation of transcription of hut DNA by glutamine synthetase. Proceedings of the National Academy of Sciences of the United States of America 71:225–229
    [Google Scholar]
  24. Wall J. D., Johansson B. C., Gest H. 1977; A pleiotropic mutant of Rhodopseudomonas capsulata defective in nitrogen metabolism. Archives of Microbiology 115:259–263
    [Google Scholar]
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