1887

Abstract

Temporal studies were made of factors associated with increased RNA synthesis in guinea pig liver during Q fever. DNA-dependent RNA polymerase activities increased immediately after infection. The major distribution of RNA polymerase classes shifted from class II to class I during infection. Ornithine decarboxylase activity was induced or stimulated soon after infection and remained elevated throughout the four-day period studied. -Adenosylmethionine decarboxylase activity increased on the first day after infection and subsequently declined. Concomitantly elevated concentrations of the polyamines putrescine, spermidine and spermine reached a maximum on the first day after infection and then decreased. A model is presented to integrate these and other results to explain how RNA synthesis may be regulated during infection.

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/content/journal/micro/10.1099/00221287-122-2-227
1981-02-01
2024-05-04
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References

  1. Baca O.G., Paretsky D. 1974; Some physiological and biochemical effects of a Coxiella burnetii lipopolysaccharide preparation on guinea pigs. Infection and Immunity 9:939–945
    [Google Scholar]
  2. Becker F., Paretsky D. 1974; Changes in liver plasma membranes during Q fever. Federation Proceedings 33:1459
    [Google Scholar]
  3. Bernier R.D., Haney T., Paretsky D. 1974; Changes in lipids of liver and plasma during Q fever. Acta virologica 18:75–80
    [Google Scholar]
  4. Bradford M.M. 1976; A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72:248–254
    [Google Scholar]
  5. Canellakis Z.N., Theoharides T.C. 1976; Stimulation of ornithine decarboxylase synthesis and its control by polyamines in regenerating rat liver and cultured rat hepatoma cells. Journal of Biological Chemistry 251:4436–4441
    [Google Scholar]
  6. Christian R.G., Paretsky D. 1977; Synthesis of ribonucleotides and their participation in ribonucleic acid synthesis by Coxiella burnetii . Journal of Bacteriology 132:841–846
    [Google Scholar]
  7. Hossenlopp P., Wells D., Chambon P. 1975; Animal DNA-dependent RNA polymerases: partial purification and properties of three classes of RNA polymerases from uninfected and adenovirus- infected HeLa cells. European Journal of Biochemistry 58:237–251
    [Google Scholar]
  8. Imai H., Shimoyama M., Yamamoto S., Tanigawa Y., Ueda I. 1975; Effect of polyamines on phosphorylation of non-histone chromatin proteins from hog liver. Biochemical and Biophysical Research Communications 66:856–862
    [Google Scholar]
  9. Inoue H., Mizutani A. 1973; A new method for isolation of polyamines from animal tissues. Analytical Biochemistry 56:408–416
    [Google Scholar]
  10. Jacob S.T., Rose K.M. 1976; Stimulation of RNA polymerases I, II and III from rat liver by spermine, and specific inhibition of RNA polymerases I by higher spermine concentrations. Biochimica et biophysica acta 425:125–128
    [Google Scholar]
  11. Jänne J., Pösö H., Raina A. 1978; Polyamines in rapid growth and cancer. Biochimica et biophysica acta241–293
    [Google Scholar]
  12. Kuehn G.D., Affolter H.-A., Atmar V.J., Seebeck T., Gubler U., Braun R. 1979; Polyamine-mediated phosphorylation of a nucleolar protein from Physarum polycephalum that stimulates rRNA synthesis. Proceedings of the National Academy of Sciences of the United States of America 76:2541–2545
    [Google Scholar]
  13. Lesch R., Reutter W.editors 1975 Liver Regeneration After Experimental Injury. New York: Stratton International Medical Book Corp.;
    [Google Scholar]
  14. Lewan L., Yngner T., Engelbrecht C. 1977; The biochemistry of the regenerating liver. International Journal of Biochemistry 8:477–487
    [Google Scholar]
  15. Lin Y.-C., Rose K.M., Jacob S.T. 1976; Evidence for the nuclear origin of RNA polymerases identified in the cytosol: release of enzymes from the nuclei isolated in isotonic sucrose. Biochemical and Biophysical Research Communications 72:114–120
    [Google Scholar]
  16. Manen C.-A., Russell D.H. 1977; Regulation of RNA polymerase I activity by ornithine decarboxylase. Biochemical Pharmacology 26:2379–2384
    [Google Scholar]
  17. Marecki N., Becker F., Baca O.G., Paretsky D. 1978; Changes in liver and L-cell plasma membranes during infection with Coxiella burnetii . Infection and Immunity 19:272–280
    [Google Scholar]
  18. Martin C.R. 1976 Textbook of Endocrine Physiology pp. 101–102 Baltimore: Williams & Wilkins Co.;
    [Google Scholar]
  19. Munro H.N., Fleck A. 1966; Recent developments in the measurement of nucleic acid in biological materials. Analyst 91:78–88
    [Google Scholar]
  20. O’Malley B.W., Means A.R. 1976; The mechanism of steroid-hormone regulation of transcription of specific eukaryotic genes. Progress in Nucleic Acid Research and Molecular Biology 19:403–419
    [Google Scholar]
  21. Pajula R.-L., Raina A., Eloranta T. 1979; Polyamine synthesis in mammalian tissues. European Journal of Biochemistry 101:619–626
    [Google Scholar]
  22. Paretsky D., Anthes M.L. 1978; Effects of infection with Coxiella burnetii on synthesis of RNA. Journal of Infectious Diseases 137:486–489
    [Google Scholar]
  23. Paretsky D., Downs C.M., Salmon C.W. 1964; Some biochemical changes in the guinea pig during infection with Coxiella burnetii . Journal of Bacteriology 88:137–142
    [Google Scholar]
  24. Raina A., Jänne J. 1975; Physiology of the natural polyamines putrescine, spermidine and spermine. Medical Biology 53:121–147
    [Google Scholar]
  25. Roeder R.G., Rutter W.J. 1969; Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms. Nature, London 224:234–237
    [Google Scholar]
  26. Russell D.H., Byus C.V., Manen C.A. 1976; Proposed model of major sequential biochemical events of a trophic response. Life Sciences 19:1297–1306
    [Google Scholar]
  27. Seiler N., Knödgen B. 1979; Determination of the naturally occurring monoacetyl derivatives of di- and polyamines. Journal of Chromatography 164:155–168
    [Google Scholar]
  28. Stueckemann J., Paretsky D. 1971; Changes in hepatic glycogen, protein and ribonucleic acid synthesis, and some effects of cortisol, during Q fever. Journal of Bacteriology 106:920–924
    [Google Scholar]
  29. Symonds G.W., Brosnan M.E. 1977; Sub-cellular localization of putrescine-dependent S-adenosyl methionine decarboxylase in rat liver. FEBS Letters 84:385–387
    [Google Scholar]
  30. Tabor C.W., Tabor H. 1976; 1,4-Diaminobutane (putrescine), spermidine, and spermine. Annual Review of Biochemistry 45:285–306
    [Google Scholar]
  31. Thompson H.A., Paretsky D. 1973; Ribonucleic acid and protein synthesis in guinea pig liver during Q fever. Infection and Immunity 7:718–724
    [Google Scholar]
  32. Yu F.-L. 1975; Increased levels of rat hepatic nuclear free and engaged RNA polymerase activities during liver regeneration. Biochemical and Biophysical Research Communications 64:1107–1115
    [Google Scholar]
  33. Yu F.-L., Feigelson P. 1971; Cortisone stimulation of nucleolar RNA polymerase activity. Proceedings of the National Academy of Sciences of the United States of America 68:2177–2180
    [Google Scholar]
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